2009, Number 1
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Rev Fac Med UNAM 2009; 52 (1)
Is the association between hyporcholesterolemia and cerebral hemorrhage?
Mendoza HFC, Flores AMG, Suárez CJA, Cruz AR, Ramos MT, Barajas PJ
Language: Spanish
References: 16
Page: 14-17
PDF size: 95.30 Kb.
ABSTRACT
Background: The spontaneous intracerebral hemorrhage (ICH) occurs in approximately 10% of all cases of cerebral vascular disease (CVD). The etiology of this condition includes vascular malformations, hypertension, and drug use. Recently attention has focused on the association between hypocholesterolemia and increased incidence of HIC.
Objectives: To determine association between hemorrhagic CVD and hypocholesterolemia.
Material and methods: Case-control study was made in the Internal Medicine Service in Hospital General Xoco.We included 88 patients, 44 with CVD hemorrhagic corroborated tomographic and 44 healthy controls. Values were determined serum cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol in all subjects. The statistical analysis was conducted by obtaining odds ratio for each variable with confidence interval to 95%.
Results: The odds ratio of risk of hemorrhagic EVC for hypocholesterolemia was 1.33 (95% CI 1.21-1.45, p ‹ 0.05).
Conclusion: The hypocholesterolemia not proved to be a risk factor for hemorrhagic CVD, however, other variables such as elevated levels of LDL-C and hypertriglyceridemia behaved as protective factors.
REFERENCES
Bonita R. Epidemiology of stroke. Lancet 1992; 339: 342-344.
American Heart Association. 2002 Heart and stroke statistical update. Dallas, Tex.: American Heart Association; 2001.
Brønnum-Hansen E, Davidsen M, Thorvaldsen P. Long-term survival and causes of death after stroke; for the danish MONICA study group. Stroke 2001;32:2131-2136.
Rothwell P, Coull AJ, Giles FM et al. Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study), for the Oxford Vascular Study. Lancet 2004; 363: 1925-33.
Sacco RL. Current epidemiology of stroke. Current review of cerebrovascular disease. Current Medicine 1993: 3-14.
Sacco RL, Wolf PA, Kannel WB et al. Survival and recurrence following stroke. The Framingham study. Stroke 1982; 13: 290-29.
Iso H, Jacobs DR, Wentworth D et al. Serum cholesterol levels and six-year mortality from stroke in 350 977 men screened for the multiple risk factor intervention trial. N Engl J Med 1989; 320: 904-910.
Tegos T, Kalodiki E, Daskalopoulou S et al. Stroke: Epidemiology, clinical picture, and risk factors. The Journal of Vascular Diseases 2000; 51(10): 793-808.
Kurth T, Everett BM, Buring JE et al. Lipid levels and the risk of ischemic stroke in women. Neurology 2007; 68: 556-562.
Sacco RL, Benson RT, Kargman DE et al. High-density lipoprotein cholesterol and ischemic stroke in the elderly: the Northern Manhattan Stroke Study. JAMA 2001; 285: 2729-2735.
Horenstein RB, Smith DE, Mosca L. Cholesterol predicts stroke mortality in the Women’s Pooling Project. Stroke 2002;33: 1863-1868. year follow-up study of farming villages in Akita, Japan. Prev Med 1980; 9: 722-740.
Tanaka H, Ueda Y, Hayashi M, Date C, Baba T, Yamashita H, Shoji H, Tanaka Y, Owada K, Detels R. Risk factors for cerebral hemorrhages and cerebral infarction in a Japanese rural community. Stroke 1982; 13: 62-73.
Iribarren C, Jacobs DR, Sadler M et al. Low total serum cholesterol and intracerebral hemorrhagic stroke: is the association confined to elderly men? The Kaiser Permanente Medical Care Program. Stroke 1996; 27: 1993-1998.
Ruíz-Sandoval, Cantú, Barinagarrementería. Intracerebral hemorrhage in young people analysis of risk factors, location, causes, and prognosis. Stroke 1999; 30: 537-541.
Synder SM, Terdiman JF, Caan B et al. Relationship of apolipoprotein E phenotypes to hypocholesterolemia. Am J Med 1993; 95(5): 480-8.
Okamura, Kadowaki, Hayakawa et al. For the NIPPON DATA80 RESEARCH GROUP* What cause of mortality can we predict by cholesterol screening in the Japanese general population? Journal of Internal Medicine 2003; 253: 169-180.