Lapadula MM, González PJ , Maskin M , Soto RJ , Kaczvinsky J, Johnson MB , Graciano-Palacios M , Stengel FM

Language: Spanish
References: 15
Page: 232-239
PDF size: 164.34 Kb.

ABSTRACT

Introduction: Ultraviolet radiation exposure cause a deleterious effect in the skin called photodamage. Tretinoin application can improve this damage, however it can also cause adverse effects. The objective of this paper is to compare the differences in tolerance and patient preference when using tretinoin 0.025% along with two different moisturizers. Material and methods: It was and open, prospective, randomized, double blinded study. Fifty sevenwomen, 35 to 55 year old with photodamaged skin, applied during a preconditioning period a different moisturizer in each side of the face. One of them contained niacinamide and the other only hydrating components. After 15 days topical tretinoin 0,025% was added. Efficacy, tolerance and preferences were evaluated. Results: We didn’t find significative differences in tolerance during the preconditioning period. Transepidermal water loss (TEWL) was significatively worse for moisturizer B. Skin texture improved for both used products. During the treatment period, tolerance was worse for moisturizer B in weeks 2 and 4. There was a more important improvement in photodamage related items for moisturizer A. TEWL were high for both products in weeks 2 and 4, diminishing afterwards. This elevation was higher for moisturizer B. Comment: topical tretinoin is well tolerated when used in combination with moisturizer creams. Niacinamide adds benefits because it helps preventing adverse events and promote desirable anti age effects of the retinoid.

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