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Colegio de Medicina Interna de México.

2007, Number 6

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Med Int Mex 2007; 23 (6)

Enalapril-induced cough, incidence and influence in reducing arterial tension

Suárez OR, García VE, Jaimes HJ

Language: Spanish
References: 23
Page: 508-511
PDF size: 150.64 Kb.


ABSTRACT

Background: Cough limits the use of ACE inhibitors in many patients despite its efficacy, wich appear to be limited in this patients.
Objective: To determine the meaning of cough on the blood pressure lowering effect of enalapril.
Methods: Patients with essential hypertension where evaluated, they received enalapril 20 mg daily. Blood pressure was measured in every visit, cough was measured with direct questioning and severity estimated according to impact con daily activities and sleep. We considered ACEI induced cough when appeared after starting enelapril and disappeared after stopping it.
Results: 61 where evaluated, 40 (66.5%) female, age were 57±12.3 years. Mean reduction of blood pressure was 12.9±2.9 (mean±SE) for systolic and 12.5±1.3 for diastolic (p = 0.0001). 9 patients had cough, 1 was not related with ACEI (incidence 13.3%/month [95%CI=5.8- 24%]), There was a statistically significant difference between cough and no-cough on its BPLE (mean 4.7 and 1.5 for diastolic and systolic). Patient compliance with drug regime was excellent in both groups.
Conclusion: Cough may be a signal of altered efficacy of ACEI in these patients and should be stoped as there will be no further change in blood pressure. Probable mechanisms are discussed.


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