2004, Number 1-2
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Plasticidad y Restauración Neurológica 2004; 3 (1-2)
Human genome. Neurological Aspects 1st part
Aguilar RF
Language: Spanish
References: 21
Page: 79-84
PDF size: 78.40 Kb.
ABSTRACT
In less than 50 years the way has been crossed from the identification of the structure of the DNA to the attainment of the human project genome. It can be this very fast to the foreseeable rate or, on the contrary very slow, and means century are a space of time very expanded, that could have shortened if it had been acted with a predetermined plan, supported by a political and economic decision, until obtaining the sequences of the genome of the human DNA. That attitude we could take before this molecule of the life as were called initially. That attitude we could take before this molecule of the life as were called initially. One is due to deal with great respect to be the carrying structure of the genes and the human inheritance, or to use it like a chemical molecule but, that there is to explode economically for good of the humanity and to obtain patents... which is a risk.
The human genome must contribute to the well-being of the humanity in prevention of the disease and promotion of the health, like element of a preventive medicine, the recent knowledge in epilepsy where has been a great influence of the genetics.
REFERENCES
Lee TE. El Proyecto Genoma Humano. Gedisa editorial 1991.
Dean H, Copeland P. EI Misterio de los genes. Vergara Editorial 1998.
Singer P. Ética Práctica. 2a Edición, Cambridge. 1984.
Dickson D. http:llwww.nature,com, 29 de junio 2000.
Susuki D, Knudtson P. Gen-Ética. EDITTECNOS. 1991.
Weber M. La Ética Protestante, y el espíritu del capitalismo. Diálogo. 53 ed. 1998.
Rubio CJ. EI Hombre y la Ética. Antropos, 1987.
Rosenberg R. An introduction to the molecular genetics of neurological diseases (Editorial). 7 Arch Neurol 1993;50:1123-27.
Treiman L, Treiman D. Genetic aspects of epilepsy. In: Wyllie 2001;151-163.
Delgado-Escueta AV, White R, Greenberg DA, Treiman U. Looking for epilepsy genes: clinical and molecular genetic studies. Adv Neurol 1986:44:77-95.
Janz D. Epilepsy with impulsive petit mal (Juvenile myoclonic epilepsy). Acta Neurol Scan 1985;72:449-59.
Berkovic SF, Scheffer LE. Epilepsies with single gene inheritance. Brain Dev 1997;19;1:13-8.
Serratosa JM, Delgado-Escueta Ay, Medina MT et al. Juvenile myoclonic epilepsy: D6S313 and D6S258 flank a 40 cM JME region. Annals of Neurology 1996;39:58-66.
Serratosa JM, Pascual-Castrovieio I, Lopez-martin V, Medina MT, Rodriguez-Bermejo V, Delgado-Escueta A. Genetics of the electroencephalographic traits associated with childhood absence epilepsy (abstract). Epilepsia 1992;33(suppl 3):74.
Bookcman K, Wang D, Korenke CG. Autosomal Dominant Glut-1 deficiency syndrome and familial epilepsy. Ann Neurol 2001;50:476-485.
Briellman RS, Jackson GD, Torn- Broers Y, Berkovic SF. Causes of epilepsies: insights from discordant monozygous twin. Ann Neurol 2001;49:45-52.
Wallace RH, Dheffer IE, Barnet S et al. Neuronal sodium-channel 1 subunit mutations in generalized epilepsy with febrile seizures plus. AM Hum Genet 2001;68:859-865.
Jouvenceau A, Euson LH, Spauschus A et al. Human epilepsy associated with dysfunction of the brain P/Q- type calcium channel. Lancet 2001;358:801-807.
Durner M, Keddache MA, Tomasini L et al. Genome scan of idiopathic generalized epilepsy: evidence for major susceptibility gene and modifying genes influencing the seizure type. Ann Neurol 2001; 49:328-335.
Johnson MR, Sander JW. The clinical impact of epilepsy genetics. J Neurol Neurosurg Phychiatry 2001;70:428-430.