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Colegio de Medicina Interna de México.

2007, Number 5

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Med Int Mex 2007; 23 (5)

Brief description of molecular

Gutiérrez SJ

Language: Spanish
References: 38
Page: 436-440
PDF size: 115.98 Kb.


ABSTRACT

Liver is in the vertebrates the only mature organ that conserves its capacity to proliferate. Cellular proliferation is given in several steps and its initial phase this given by the activation of transcription factors (mainly NFκB and STAT3) and the synthesis of growth factors (TNF, HGF, IL-6, TGFα) that they are the elements that direct and maintain the progression of the hepatocyte from G0 phase to G1 phase of the cell cycle. This transition to G1 can determine that the hepatocyte takes some of the following routes: 1) to continue toward the S-phase of the cell cycle and to duplicate their DNA; 2) to miscarry the cellular cycle and to return to the phase G0, and 3) to carry out the apoptosis of the cell. Activation of early responsive genes and transcription factors are the first events that happen so that a hepatocyte begins the G1 phase of the cell cycle. Early activation of genes is regulated by diverse growth factors which take place in a synchronous way to allow the cell progression toward its duplication. The knowledge of the factors that determine the proliferation of the hepatocyte in experimental conditions can be a great assistant in the therapeutic processes of cancer disease or in cellular transplant.


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