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Colegio de Medicina Interna de México.

2007, Number 3

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Med Int Mex 2007; 23 (3)

LDL-cholesterol in patients with elevated triglycerides: selected population study

Héctor García AF, Estrada ML, Estrada GRA, Jonguitud DV, Parra OI

Language: Spanish
References: 24
Page: 183-187
PDF size: 201.28 Kb.


ABSTRACT

Background: Since its description, it is known that Friedewald’s formula, method used to calculate LDL-cholesterol, is inaccurate if triglycerides are over 400 mg/dL and inadequate if triglycerides are over 200 mg/dL.
Objective: To describe the frequency in which LDL-cholesterol is obtained when levels of triglycerides are over 200 mg/dL.
Patients and methods: There were analyzed 355 patients, 190 (53.5%) female and 165 (46.5%) male. They came to Laboratorios Clinicos de Puebla to obtain glucose’s curve of tolerance with 75 g glucose load, different densities cholesterol and triglycerides. Value of LDL-cholesterol level was calculated by Friedewald’s formula.
Results: Blood sugar diagnosis (American Diabetes Association criteria) was normal in 139 (38.9%) patients, had abnormal fasting glucose in 166 (46.8%) and 51 (14.3%) had diabetes. Glucose after two hours diagnosis (WHO criteria) was normal in 219 (61.7%) patients, intolerant to glucose in 70 (19.7%) and with diabetes in 66 (18.6%). Final diagnosis informs that glucose was normal in 123 (34.6%) patients, 93 (26.2%) had upset fasting glucose, 62 (17.5%) were intolerant to glucose and 77 (21.7%) had diabetes. LDL-cholesterol measured by Friedewald’s formula was right in 238 (67%) patients, with les than 200 mg/dL triglycerides; 90 patients (25.4%) had triglycerides between 200-400 mg/dL, and 27 (7.6%) had more than 400 mg/dL. Among the 77 patients with diabetes diagnosis, 49 (63.6%) had LDL-cholesterol with less than 200 mg/dL triglycerides level, 22 (28.6%) had triglycerides between 200-400 mg/dL and 6 (7.8%) had more than 400 mg/dL.
Conclusions: If 200 mg/dL level of triglycerides is not the cutoff point value for LDL-cholesterol calculation, by traditional formula, almost 40% of population will have false LDL values. We need to change the way we measure LDL-cholesterol to patients with triglycerides level higher than 200 mg/dL.


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