García-Álvarez MN, Plata-Muñoz JJ, Medina-Franco H

Language: Spanish
References: 17
Page: 244-248
PDF size: 77.66 Kb.

ABSTRACT

Objective: Analyze retrospectively the clinical, histopathological and surgical characteristics of patients with Ménétrier´s disease (MD) at our Institution. Background data: Ménétrier´s disease (MD) includes hipertophy of gastric mucosa, hipo or hiperchloridria and severe hipoalbuminemia. In the literature, it has been underestimated its relationship with the development of gastric carcinoma. Methods: We analyzed retrospectively the clinical trials of patients with MD treated surgically at our Institution during the last three decades (From 1970 through 2002). Results: Three patients with clinical diagnosis of MD underwent total gastrectomy during the study period. All of them were corroborated histopathologically and in one patient carcinoma in situ was demonstrated in the surgical specimen. Conclusions: There is a very limited experience with surgical treatment of MD and it is limited to patients who have severe hipoalbuminemia or associated malignant disease. However, accordig to our experience and literature review, surgical treatment should be considered early in the course of the disease for the relationship between MD and gastric adenocarcinoma.

REFERENCES

1. Sleisenger M, Fordtran J, Scharschmidt B, Feeldman M. Gastrointestinal disease. Pathophysiology/ diagnosis/ management. 5a. Ed. Vol. 1. Editorial Saunders; 1993, p. 561-3.

2. Coffey RJ, Romano M, Goldenring J, Roles for transforming growth factor-alpha in the stomach. J Clin Gastroenterol 1995; 21: S36-9.

3. Settle SH, Washington K, Lind C, Itsokowitz S, et.al. Chronic treatment of Menetrier’s disease with Erbitux: clinical efficacy and insight into pathophysiology. Clin Gastroenterol Hepatol 2005; 3: 654-9.

4. Kim J, Cheong JH, Chen J, et.al. Menetrier’s disease in korea: report of two cases and review of cases in a gastric cancer prevalent region. Yonsei Med J 2004; 30(45): 555-60.

5. Santolaria PS, Conde GR, Abascal AM, et.al. Resolution of Menetrier’s disease after eradication of Helicobacter pylori infection. Gastroenterol Hepatol 2004; 27: 357-61.

6. Dykes CM. Ménetrier’s disease: Case estudy in the quality of life. Gastroenterol Nurs 2003; 26: 3-6.

7. Wilkerson ML, Meschter SC, Brown RE. Menetrier’s disease presenting with iron deficiency anemia. Ann Clin Lab Sci 1998; 28: 14-8.

8. Watanabe K, Beinborn M, Nagamatsu S, et. al. Menetrier’s disease in a patient with Helicobacter pylori infection is linked to elevated glucagons-like peptide-2 activity. Scand J Gastroenterol 2005; 40: 477-81.

9. Okanobu H, Hata J, Haruma K, et al. Giant gastric folds: differential diagnosis at US. Radiology 2003; 226: 686-90.

10. Schulz J, Kohler B, Wegener K, Riemann JF, Menetrier’s disease-a rare cause of a protein deficiency syndrome, Dtsch Med Wochenschr 1992; 3(117): 531-4.

11. Raderer M, Oberhuber G, Templ E, et.al. Successful symptomatic management of a patient with Menetrier’s disease with long-term antibiotic treatment, Digestion. 1999; 60: 358-62.

12. Mattig H, Mahnke W. Localized Menetrier disease and stomach cancer. Dtsch Z Verdau Stoffwechselkr 1984; 44: 67-76.

13. Stamm B. Localized hiperplastic gastropathy of the mucous cell- and mixed cell-type (localized Ménétrier’s disease): a report of 11 patients. Am J Surg Pathol 1997; 21: 1334-42.

14. Kapadia CR. Gastric atrophy, metaplasia, and dysplasia: a clinical perspective. J Clinical Gastroenterol 2003; 36: S29-36.

15. Ohyama I, Ohmiya N, Niwa Y, Shirai K, et al. The association between tumour necrosis factor-alpha gene polymorphism and the susceptibility to rugal hyperplastic gastritis and gastric carcinoma. Eur J Gastroenterol Hepatol 2004; 16: 693-700.

16. Melita P, Calbo L, Cucinotta E, Gorgone S, Palmeri R, Pergolizzi FP, et al. Gastric precancerous conditions, Chir Ital 1995; 47: 54-8

17. Haentjens P, Willems G. Precancerous lesions in the stomach. Acta Chir Belg 1984; 84: 277-82.