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2008, Number 3

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Bioquimia 2008; 33 (3)

Advances in the interaction between mycoplasmas and human spermatozoa

López-Hurtado M, Guerra-Infante FM

Language: Spanish
References: 51
Page: 115-121
PDF size: 112.82 Kb.


ABSTRACT

The purpose of this revision is to explore and to analyze the recent discoveries on the adherence and penetration of some Mycoplasma species and to show the role of these bacteria in the development of the masculine infertility. Since 70´ years some Mycoplasma species has been considered as pathogens of spermatic cells. However, several in vivo studies do not have confirmed the changes in the spermatic activity, which has been observed in vitro studies. These in vitro studies have shown that Mycoplasma hominis, Mycoplasma vaginalis and Ureaplasma urealyticum have the ability to attach and internalize to the human spermatic cells seemingly without affecting the viability of the same one. The interaction between human spermatozoids and these microorganisms produce small morphological changes of tails and middle region of spermatic cells, this interaction provoke the decrease in mobility and in acrosomic reaction too. These findings suggest that attachment and invasiveness are early events during the infectious process, but their association with reproductive failure must be studied extensively.


REFERENCES

  1. Forbes BA, Sahm DF, Weisfeld AS, [Eds.] Cell wall-deficient bacteria: Mycoplasma and Ureaplasma. In: Diagnostic Microbiology. USA: Mosby Editorial; 1998. p. 766-74.

  2. Taylor RD. Infections due to species of Mycoplasma and Ureaplasma: an update. Clin Infec Dis. 1996; 23: 671-84.

  3. Sánchez-Vargas FM, Gómez-Duarte GM. Mycoplasma pneumoniae- an emerging extra-pulmonary pathogen. Clin Microbiol Infect. 2008; 14: 105-17.

  4. Taylor-Robinson D. The role of Mycoplasmas in pregnancy outcome. Best Pract Res Clin Obstet Gynaecol. 2007; 21: 425-38.

  5. Haggerty CL. Evidence for role of Mycoplasma genitalium in pelvic inflammatory disease. Current Opinion Infec Dis. 2008; 21: 65-9.

  6. Farong K, James G, Zhenfang M, Gordon S, Wang B, Gilbert GL. Phylogenetic analysis of Ureaplasma urealyticum – support for establishment of a new species, Ureaplasma parvum. Inter J Syst Bacter. 1999; 49: 1879-89.

  7. Bove JM. Molecular features of Mollicutes. Clin Infect Dis. 1993; 17(Suppl 1): S10-S31.

  8. Razin S, Yoguev D, Naot Y. Molecular biology and pathogenicity of mycoplasmas. Microbiol Mol Biol Rev. 1998; 162: 1094-156.

  9. Baseman JB, Tully JG. Mycoplasmas: Sophisticated, reemerging and burdened by their notoriety. Emerg Infect Dis. 1997; 3: 1-59.

  10. Baseman JB, Lange M, Criscimagna NL, Giron JA, Thomas CA. Interplay between mycoplasmas and host target cells. Microb Pathog. 1995; 19: 105-16.

  11. Jensen JS, Blom J, Lind K. Intracellular location of Mycoplasma genitalium in cultured Vero cells as demonstrated by electron microscopy. Int J Exp Pathol. 1994; 75: 91-8.

  12. Styler M, Shapiro SS. Mollicutes (mycoplasma) in infertility. Fertil Steril. 1985; 44: 1-11.

  13. Lusk MJ, Konecny P. Cervicitis: a review. Current Opinion Infec Dis. 2008; 21: 65-9.

  14. Bezold G, Politch JA, Kiviat NB, Kuypers JM, Wolff H, Anderson DJ. Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia. Fertil Steril. 2007; 87: 1087-97.

  15. Andrade-Rocha FT. Ureaplasma urealyticum and Mycoplasma hominis in men attending for routine semen analysis. Prevalence, incidence by age and clinical settings, influence on sperm characteristics, relationship with the leukocyte count and clinical value. Urol Int. 2003; 7: 377-81.

  16. Gilbert GL, Weisberg E. Infertility as an infectious disease - epidemiology and prevention. Bailliere´s Clin Obstet Gynaecol. 1993; 7: 159-81.

  17. Cassell GH, Cole BC. Mycoplasmas as agents of human disease. N Engl J Med. 1981; 304: 80-9.

  18. Meseguer MA, Martinez-Ferrer M, De Rafael L. Differential counts of Ureaplasma urealyticum in male urological patients. J Infect Dis. 1984; 149: 65-9

  19. Karchmer S, Barros JC. Esterilidad conyugal. En: PAC GO-1, Libro 6 Ginecología. México: Schering-Intersistemas S.A. de C.V; 1998. p. 7-49.

  20. Gdoura R, Kchaou W, Ammar-Keskes L, Chakroun N, Sellemi A, Znazen A, et al. Assessment of Chlamydia trachomatis, Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, and Mycoplasma genitalium in semen and first void urine specimens of asymptomatic male partners of infertile couples. J Androl. 2008; 29:198-206.

  21. Fowlkes DM, Macleod J, O´leary WM. T-mycoplasma and human infertility: correlation of infection with alterations in seminal parameters. Fertil Steril. 1975; 26:1212-8.

  22. Nuñez CR, Caballero P, Redondo C, Baquero F, Martínez FP, Meseguer MA. Ureaplasma urealyticum reduces motility and induces membrane alterations in human spermatozoa. Hum Reprod. 1998; 13: 2756-61.

  23. Gdoura R, Kchaou W, Chaari C, Znazen A, Keskes L, Rebai T, et al. Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis and Mycoplasma genitalium infections and semen quality of infertile men. BMC Infect Dis. 2007; 7: 129-37.

  24. Rose BI, Scott BS. Sperm motility, morphology, hyperaction, and ionophore-induced acromosome reactions after overnight incubation with mycoplasmas. Fertil Steril. 1994; 61: 341-8.

  25. Reichart M, Kahane I, Bartoov B. In vivo and in vitro impairment of human and ram sperm nuclear chromatin integrity by sexually transmitted Ureaplasma urealyticum infection. Biol Reprod. 2000; 63: 1041-8.

  26. Busolo F, Zancheta R. The effect of Mycoplasma hominis and Ureaplasma urealyticum on hamster egg in vitro penetration by human spermatozoa. Fertil Steril. 1985; 43: 110-4.

  27. Fowlkes DM, Dooher GB, O’Leary WM. Evidence by scanning electron microscopy for an association between spermatozoa and T-mycoplasma in men of infertile marriage. Fertil Steril. 1975; 26: 1203-11.

  28. Toth A, Swenson CE, O´leary WM. Light microscopy an aid in predicting Ureaplasma infection in human semen. Fertil Steril. 1978; 30: 586-91.

  29. Busolo F, Zancheta R, Bertolini G. Mycoplasmic localization patterns on spermatozoa from infertile men. Fertil Steril. 1984; 42: 412-17.

  30. Fernandez JL, Ramos B, Santiso R, Agarwal A, Gosalvez J, Gallegos G. Frequency of sperm cells with fragmented DNA in males infected with Chlamydia trachomatis and Mycoplasma sp, determined with the sperm chromatin dispersion (SCD) test. Fertil Steril. 2007; 88 (Suppl1): S5.

  31. Miller RA, Britigan BE. Role of oxidants in microbial pathophysiology. Clin Microbiol Rev. 1997; 10: 1-18.

  32. Kannan TR, Baseman JB. Hemolytic and hemoxidative activities in Mycoplasma penetrans. Infect Immun. 2000; 68: 6419-22.

  33. Potts JM, Sharma R, Pasqualotto F, Nelson D, Hall G, Agarwal A. Association of Ureaplasma urealyticum with abnormal reactive oxygen species levels and absence of leukocytospermia. J Urol. 2000; 163: 1775-8.

  34. Svenstrup HF, Fedder J, Abraham PJ, Birkelund S, Christiansen G. Mycoplasma genitalium attaches to human spermatozoa. Hum Reprod. 2003; 18: 2103-9.

  35. Díaz GFJ, Herrera MAP, Giono CS, Guerra IFM. Mycoplasma hominis attaches to and locates intracellulary in human spermatozoa. Human Reprod. 2006; 21: 1591-8.

  36. Lingwood C, Shramayr S, Quinn P. Male germ cell specific sulfogalacto-glycerolipid is recognized and degraded by mycoplasmas associated with male infertility. J Cell Physiol. 1990; 142: 170-6.

  37. Olson LD, Gilbert AA. Characteristics of Mycoplasma hominis adhesion. J Bacteriol. 1993; 175: 3224-7.

  38. Lingwood CA, Quinn PA, Wilansky S, Nutikka A, Ruhnke HL, Miller RB. Common sulfoglycolipid receptor for Mycoplasmas involved in animal and human infertility. Biol Reprod. 1990; 43: 694-7.

  39. Vos JP, López-Cardozo M, Gazella BM. Metabolic and functional aspects of sulfogalactolipids. Biochim Biophys Acta. 1994; 1211: 125-49.

  40. Lingwood CA. Colocalization of sulfogalactosylacylalkylglicerol (SGG) and its binding protein during spermatogenesis and sperm maturation. Topology of SGG defines a new testicular germ cell membrane domain. Biochem Cell Biol. 1986; 64: 984-93.

  41. Weerachatyanukul W, Probodh I, Kongmanas K, Tanphaichitr N, Johnston LJ. Visualizing the localization of sulfoglycolipids in lipid raft domains in model membranes and sperm membrane extracts. Biochim Biophys Acta. 2007; 1768: 299-310.

  42. Weerachatyanukul W, Rattanachaiyanont M, Carmona E, Furimsky A, Mai A, Shoushtarian A, et al. Sulfogalactosylglycerolipid is involved in human gamete interaction. Mol Reprod Dev. 2001; 60: 569-78.

  43. Boulanger J, Faulds D, Eddy EM, Lingwood CA. Members of the 70 kDa heat shock protein family specifically recognize sulfoglycolipids: Role in gamete recognition and mycoplasma-related infertility. J Cell Physiol. 1995; 165: 7-17.

  44. Mamelak D, Mylvaganam M, Whetstone H, Hartmann E, Lennarz W, Wyrick PB, et al. Hsp 70s contain a specific sulfogalactolipid binding site. Differential aglycone influence on sulfogalactosyl ceramide binding by recombinant prokaryotic and eukaryotic hsp 70 family members. Biochemistry. 2001; 40: 3572-82.

  45. Bohring C, Krause E, Habermann B, Krause W. Isolation and identification of sperm membrane antigens recognized by antisperm antibodies, and their possible role in immunological infertility disease. Mol Hum Reprod. 2001; 7: 113-8.

  46. Miller D, Brough S, Al-Harbi O. Characterization and cellular distribution of human spermatozoal heat shock proteins. Hum Reprod. 1992; 7: 637-45.

  47. Zakeri ZF, Wolgemuth DJ. Developmental-stage-specific expression of the hsp 70 gene family during differentiation of the mammalian male germ line. Mol Cell Biol. 1987; 7: 1791-6.

  48. Eddy EM. Role of heat shock protein HSP70-2 in spermatogenesis. Rev Reprod. 1999; 4: 23-30.

  49. Levasseur M, McDougall A. Sperm-induced calcium oscillations at fertilization in ascidians are controlled by cyclin B1-dependent kinase activity. Development. 2000; 127: 631-41.

  50. Mernaugh GR, Dallo SF, Holt SC, Baseman JB. Properties of adhering and nonadhering populations of Mycoplasma genitalium. Clin Infect Dis. 1993; 17(Suppl. 1): S69-S78.

  51. Burgos R, Pich OQ, Ferrer-Navarro M, Baseman JB, Querol E, Piñol J. Mycoplasma genitalium P140 and P110 cytadhesins are reciprocally stabilized and required for cell adhesion and terminal-organelle development. J Bacteriol. 2006; 188: 8627-837.




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