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Anales de Otorrinolaringología Mexicana

2007, Number 3

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Otorrinolaringología 2007; 52 (3)

Head and neck osteosarcoma associated with pregnancy. Two cases report

Gerzso NF, Castro HG, Landeros AL, Castillo VB

Language: Spanish
References: 22
Page: 122-126
PDF size: 212.60 Kb.


ABSTRACT

Head and neck osteosarcoma is a rare disease, it has been reported in 6% of the cases, and its relationship to pregnancy is unknown. We received two cases in the department of otolaryngology which would be presented. The first is a thirty-two-year-old patient with an uncomplicated pregnancy of 35.1 gestational weeks, whom is detected through a CT scan with a neoplasia involving the mandible. An open biopsy reports a high grade condroblastic subtype osteosarcoma. Pregnancy is interrupted and the patient is referred to the Instituto de Cancerología, where it’s performed a right anterolateral mandibulectomy, with condyle preservation and iliac crest reconstruction. The patient dies five months after a locoregional recidive, and a course of radio and chemotherapy. The second case is a female twenty-fouryear-old patient with an uncomplicated pregnancy which in the last month begins with progressive nasal obstruction, cheek hypoesthesia, exophthalmia and epistaxis. A CT scan reveals a mass on the left nasal passage, involving the anterior and posterior ethmoid and ipsilateral maxillary sinus with erosion of the orbit floor. An incisional biopsy reports an osteosarcoma without indicating subtype. The patient is referred to the Instituto de Cancerología, where is being treated with chemo and radiotherapy. There was no subsequent following because she didn’t assist to the scheduled visits. These two cases show the infrequent presentation of the osteosarcoma associated to pregnancy. To date there are no reports of this coexistence, but the literature revision of the management of cancer during pregnancy, and of the head and neck presentation, helps to understand the logic of treatment and prognostic of this rare disease.


REFERENCES

  1. Ha PK, Eisele DW, Frassica FJ, Zahurak ML, McCarthy EF. Osteosarcoma of the head and neck: a review of the John Hopkins experience. Laryngoscope 1999;109:964-69.

  2. Bennett JH, Thomas G, Evans AW, Speight PM. Osteosarcoma of the jaws: a 30-year retrospective review. Oral Maxilofac Pathol 2000:90(3);323-33.

  3. Bertoni F, Dallera P, Bacchini P, Marchetti C, Campobassi A. The Instituto Rizzoli-Beretta experience with osteosarcoma of the jaw. Cancer 1991:68(7):1555-63.

  4. Lindqvist C, Teppo L, Sane J. Osteosarcoma of the mandible: analysis of nine cases. J Oral Maxillofac Surg 1986;44:759-64.

  5. Ruiz-Godoy RL, Meneses-Garcia A, Mosqueda-Taylor A, De la Garza-Salazar J. Well-differentiated intraosseous osteosarcoma of the jaws: experience of two cases from the Instituto Nacional de Cancerología, México. Oral Oncol 1999;35:530-6.

  6. Gorsky M, Epstein JB. Craniofacial osseous and chondromatous in British Columbia—a review of 34 cases. Oral Oncology 2000;36:27-31.

  7. Maxwell C, Barzilay B, Shah V, Wunder JS, Bell R, Farine D. Maternal and neonatal outcomes in pregnancies complicated by bone and soft tissue tumors. Obstet Gynecol 2004;104(2):344-8.

  8. Gorsky M, Epstein, JB. Head and neck and intra-oral soft tissue sarcomas. Oral Oncology 1998;34:292-6.

  9. Pavlidis NA. Coexistence of pregnancy malignancy. Oncologist 2002;7:279-87.

  10. Lee Y, Van Tassel P, Nauert C, Raymond AK, Edeiken J. Craniofacial osteosarcomas: plain film, CT and MR findings in 46 cases. AJR 1988:150;1397-402.

  11. Yee S, Songra A, Ali N. Ultrasound features of osteosarcoma of the mandibule—a first report. Oral Surg Oral Med Oral Pathol 2001;92(5):582-6.

  12. Patel SG, Meyers P, Huvos AG, Wolden S, Singh B, et al. Improved outcomes in patients with osteogenic sarcoma of the head and neck. Cancer 2002:95(7);1495-503.

  13. Smeele LE, Kostense PJ, Van der Waal I. Effect of chemotherapy on survival of craniofacial osteosarcoma: a systematic review of 201 patients. J Clin Oncol 1997;15(1):363-7.

  14. Mardinger O, Givol N, Talmi YP. Osteosarcoma of the jaw. The Chaim Sheba Medical Center experience. Oral Surg Oral Med Oral Pathol 2001;91(4):445-51.

  15. Okinaka Y, Masahiro T. Osteosarcoma of the maxilla: report of a case and review of the literature concerning metastasis. J Oral Maxillofac Surg 1997;55:1177-81.

  16. Schwartz JL, Mozurkewich EL, Johnson TM. Current management of patients with melanoma who are pregnant, want to get pregnant, or do not want to get pregnant. Cancer 1997:(9);2130-3.

  17. Alexander A, Samlowski WE, Grossman CS. Metastatic melanoma in pregnancy: risk of transplacental metastases in the infant. J Clin Oncol 2003;21(11):2179-86.

  18. Honore LH, Brown LB. Intervillous placental metastasis with maternal myeloid leukemia. Arch Pathol Lab Med 1990;114:450.

  19. Baerge RN, Johnson D, Moore T. Maternal melanoma metastasis to the placenta. Arch Pathol Lab Med 1997;121:508-11.

  20. Berghella V, Broth RE, Chapman AE. Metastatic unknown primary tumor presenting in pregnancy as multiple cerebral infarcts. Obstet Gynecol 2003;101:1060-2.

  21. Potter JF, Schoeneman M. Metastasis of maternal cancer to the placenta and fetus. Cancer 1970;25(2):380-8.

  22. Catlin EA, Roberts JD, Erana R, et al. Transplacental transmission of natural-killer-cell lymphoma. New Engl J Med 1999;341(2):85-91.




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