medigraphic.com

2008, Number 4

<< Back Next >>

Cir Cir 2008; 76 (4)

Cystic neoplasms of the pancreas

Jordán-Pérez B, Javier-Haro F, Gómez-Herrera E, Hermosillo-Sandoval JM, Andrade-Madrid R, Prieto-Díaz CE

Language: Spanish
References: 23
Page: 299-303
PDF size: 93.81 Kb.


ABSTRACT

Background: Cystic neoplasms of the pancreas represent between 5% and 10% of all pancreatic tumors. Due to their malignant potential, surgery is indicated. Because of the uncommon nature of this pathology, the aim of this study was to present a series of six patients who were operated on for a cystic tumor and to analyze the morphological characteristics, surgical experience and follow-up.
Methods: This was a retrospective study. Clinical files were studied, as well as surgical and pathological registries from patients diagnosed with cystic neoplasms of the pancreas. Five females and one male were included with mean ages of 54 ± 15 years. The main symptom was abdominal pain.
Results: Clinical course and CT scan results were the criteria for suspecting the diagnosis. In four out of six patients, the tumor was located within the body and tail of pancreas. The most frequent intervention was distal pancreatectomy. There was no mediate operative mortality in a 30-day period. Histopatological diagnoses were three serum cystoadenomas, two mucinous cystoadenomas and one cystoadenocarcinoma. After a 4-year follow-up, no recurrences of tumor have been reported in the surviving patients.
Conclusions: The natural history of cystic neoplasms of the pancreas is generally benign, but complications may occur by direct invasion of neighboring structures. Clinical course, tomography, pancreatography and punction are fundamental for its treatment.


REFERENCES

  1. Wenig B, Heffej C. Benign and Malignat Tumors of the Pancreas. In: Odze R, Goldblum J, eds. Surgical pathology of the gastrointestinal tract, liver, biliary tract and pancreas. Philadelphia: Saunders;2004. pp. 639-695.

  2. Fernandez-del Castillo C, Warshaw AL. Cystic tumors of the pancreas. Surg Clin North Am 1995;75:1001-1016.

  3. Mozan AA. Cystadenoma of the pancreas. Am J Surg 1951;81:204-214.

  4. Talamini MA, Pitt HA, Hruban RH, Boitnott JK, Coleman JA, Cameron JL. Spectrum of cystic tumors of the pancreas. Am J Surg 1992;163:117–124.

  5. Compagno J, Oertel JE. Microcystic adenomas of the pancreas. Glycogenrich cystadenomas. Am J Clin Pathol 1978;69:281–282.

  6. Delcore R, Thomas JH, Forster J, Hermreck AS. Characteristics of cystic neoplasms of the pancreas and results of aggressive surgical treatment. Am J Surg 1992;164:437–442.

  7. Aristi-Urista G, Güereña-Elizalde A, Ramos-Cruz R. Cistadenoma seroso del páncreas (“adenoma microquístico”). Informe de siete casos. Rev Med Hosp Gen Mex 2002;65:15-22.

  8. Magaña SIJ, Silva OJ, De la Torre MG. Belmonte Montes C, Hernández AC. Cistadenoma seroso de páncreas. A propósito de 5 pacientes. Cir Gen 1997;19:302-308.

  9. Sánchez-Fernández P, Harris A, Castillo-González A, Blanco-Benavides R, Luque-De León E, Robledo-Ogazón F. Cistadenocarcinoma mucinoso de páncreas. Informe de un caso. Cir Cir 1998;66:196.

  10. Juárez-Corona D, Flores-Gómez S, Senties-Carbajal S, Mendoza M. Neoplasias quísticas primaria del páncreas: informe de dos pacientes uno con cistadenoma y otro con cistadenocarcinoma. Cir Gen 2001;23:177-181.

  11. Pérez-Perales JE. Neoplasia quística del páncreas. Informe de un paciente. Cir Gen 2004;26:321-324.

  12. Sarr M, Carpenter H, Prabhakar L, Orchard T, Hughes S, van Heerden JA. Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms? Ann Surg 2000;231:205-212.

  13. Sohn TA, Yeo CJ, Cameron JL, Iacobuzio-Donahue CA, Hruban RH, Lillemoe KD. Intraductal papillary mucinous neoplasms of the pancreas: an increasingly recognized clinicopathologic entity. Ann Surg 2001;234:313–322.

  14. Le Borgne J, de Calan L, Partensky C. Cystadenomas and cystadenocarcinomas of the pancreas: a multiinstitutional retrospective study of 398 cases. Ann Surg 1999;230:152.

  15. Pyke CM, van Heerden JA, Colby TV, Sarr MG, Weaver AL. The spectrum of serous cystadenoma of the pancreas. Ann Surg 1992;215:132–139.

  16. Ahrendt SA, Komorowski RA, Demeure MJ, Wilson SD, Henry A. Cystic pancreatic neuroendocrine tumors is preoperative diagnosis possible? J Gastr Surg 2002;6:66-74.

  17. Alsaad K, Chetty R. Mini-symposium: pathology of the exocrine pancreas. Serous cystic neoplasms of the pancreas. Curr Diagn Pathol 2005;11:102-109.

  18. Traverso LW, Peralta EA, Ryan JA, Korazek RA. Intraductal neoplasms of the pancreas. Am J Surg 1998;175:426-432.

  19. Fernández JA. Tumores quísticos del páncreas: revisión de la literatura. Cir Esp 2003;73:297-308.

  20. Takaori K, Kobashi Y, Matsusue S, Matsui K, Yamamoto T. Clinicopathological features of pancreatic intraepithelial neoplasias and their relationship to intraductal papillary-mucinous tumors. J Hepatobiliary Pancreat Surg 2003;10:125–136.

  21. Tanaka M, Chari S, Adsay V, Fernández-del Castillo C, Falconi M, Shimizu M, et al. International Consensus Guidelines for Management of Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms of the Pancreas. Pancreatology 2006;6:17–32

  22. Sperti C, Pasquali C, Guolo P, Polverosi R, Liessi G, Pedrazzoli S. Serum tumor markers and cyst fluid analysis are useful for the diagnosis of pancreatic cystic tumors. Cancer 1998;78:237-243.

  23. Mckay D, Marron C, Mathew S, Diamond T. Management of cyst tumours of the pancreas. ANZ J Surg 2004;74:627-630.




2020     |     www.medigraphic.com