Coronel-Pérez IM, Rodríguez-Pichardo A, García-Bravo B, Rodríguez-Rey EM, Camacho FM

Language: Spanish
References: 27
Page: 189-194
PDF size: 231.11 Kb.

ABSTRACT

Lupus erythematosus (LE) is a sistemic disease with cutaneous manifestations in more than 80% of the patients. The aim of the study is to know the incidence of manifestations at oral mucosa and scalp, which are frequently unnoticed to the physician and the patient. Moreover, we evaluated the efficacy of topical immunomodulators in all the types of LE. Sixty three patients diagnosed of LE who came to a consultation at the Department of Dermatology at the Virgen Macarena Universitary Hospital from september to december of 2005 were reviewed. We included the systemic, subacute and discoid forms of LE. Demographic data, clinical types, location of the lesions, photoexposition, serology, histopathology and treatment followed by the patients were considerated.
We observed a high proportion of lesions at the oral mucosa and scalp. Finally, we obtained good therapeutical results using topical immunomodulators in all clinical types of lupus.

REFERENCES

1. D’Cruz DP. Systemic lupus erythematosus. BMJ 2006;332:890-4.

2. Parodi A, Caproni M, Cardinali C, Bernacchi E, Fuligni A, De Panfilis G et al. Clinical, histological and immunopathological features of 58 patients with subacute cutaneous lupus erythematosus. Dermatology 2000;200:6-10.

3. Ackerman LS. Sex hormones and the genesis of autoimmunity. Arch Dermatol 2006;142;371-6.

4. Scheinfeld N, Deleo VA. Photosensitivity in lupus erythematosus. Photodermatol Photoimmunol Photomed 2004;20:272-9.

5. Sanders CJG, Van Weelden H, Kazzaz GAA, Sigurdsson V, Toonstra J, Bruijnzeel-Koomen CAFM. Photosensitivity in patients with lupus erythematosus: a clinical and photobiological study of 100 patients using a prolonged phototest protocol. Br J Dermatol 2003;149:131-7.

6. Krause I, Shaga I, Molad Y, Guedj D, Weinberger A. Seasons of the year and activity of SLE and Behçet´s disease. Scand J Rheumatol 1997;26:435-9.

7. Trüeb RM. Hair and nail involvement in lupus erythematosus. Clin Dermatol 2004;22:139-47.

8. Wilson CL, Burge SM, Den D, Dawber RPR. Scarring alopecia in discoid lupus erythematosus. Br J Dermatol 1992;126:307-14.

9. Fabbri P, Amato L, Chiarini C, Moretti S, Massi D. Scarring alopecia in discoid lupus erythematosus: a clinical, histopathologic and immunopathologic study. Lupus 2004; 13:455-62.

10. Wysenbeek AJ, Leibovici L, Amit M, Weinberger A. Alopecia in systemic lupus erythematosus. Relation to disease manifestations. J Rheumatol 1991;18:1185-6.

11. Biaggi Ferraz L, De Almeida FA, Vasconcellos MRA, Bosi Ferraz M. Alopecia impairs the quality of life of patients with lupus erythematosus. Arch Dermatol 2006;142:110.

12. Orteu CH, Buchanan JAG, Hutchison I, Leigh IM, Bull RH. Systemic lupus erythematosus presenting with oral mucosal lesions: easily missed? Br J Dermatol 2001;144:1219-23.

13. Schiodt M. Oral discoid lupus erythematosus II. Skin lesions and systemic lupus erythematosus in sixty-six patients with 6 year follow-up. Oral Surg 1984;57:177-80.

14. Provost TT, Watson R, Simmons-O´Brien E. Anti-Ro (SS-A) antibody positive Sjögren’s/lupus erythematosus overlap syndrome. Lupus 1997;6:105-11.

15. Manoussakis MN, Georgopoulou C, Zintzaras E, Spyropoulou M, Stavropoulou A, Skopouli FN, Moutsopoulos HM. Sjögren’s syndrome associated with systemic lupus erythematosus: clinical and laboratory profile and comparison with primary Sjögren syndrome. Arthritis Rheum 2004;50:882-91.

16. Ferahbas A, Utas S, Canoz O, Atasavun C. The coexistence of subacute cutaneous lupus erythematosus and psoriasis. J Eur Acad Dermatol Venereol 2004;18:390-1.

17. Kontochristopoulos GJ, Giannadaki M, Doulaveri G, Christofidou E, Zakopoulou N. Psoriasis coexisting with subacute cutaneous lupus erythematosus. J Eur Acad Dermatol Venereol 2004;18:385-6.

18. Borbujo J, Calvo JP, Cortés L, Zamora E. Subacute lupus erythematosus and psoriasis. Rev Clin Esp 1998;198:116.

19. Murata J, Shimizu T, Tateishi Y, Abe R, Shimizu H. Coexistence of a systemic lupus erythematosus and porphyria cutanea tarda. Case successfully improved by avoidance of sun exposure. Int J Dermatol 2006;45:435-7.

20. Filiotou A, Vaiopoulos G, Capsimali V, Stavrianeas N, Kaloterakis A. Acute intermittent porphyria and systemic lupus erythematosus: report of a case and review of the literature. Lupus 2002;11:190-2.

21. De Jong EM, Van der Kerkhof PC. Coexistence of palmoplantar lichen planus and lupus erythematosus with response to treatment using acitretin. Br J Dermatol 1996:134:538-41.

22. Grabbe S, Kolde G. Coexisting lichen planus and subacute cutaneous lupus erythematosus. Clin Exp Dermatol 1995;20:249-54.

23. Kanekura T, Yoshii N, Terasaki K, Miyoshi H, Kanzaki T. Efficacy of topical tacrolimus for treating the malar rash of systemic lupus erythematosus. Br J Dermatol 2003;148:353-6.

24. Lampropoulos CE, Sangle S, Harrison P, Hughes GRV, D´Cruz DP. Topical tacrolimus therapy of resistant cutaneous lesions in lupus erythematosus: a possible alternative. Rheumatology 2004;43:1383-5.

25. Drüke A, Gambichler T, Altmeyer P, Freitag M, Kreuter A. 0.1% tacrolimus ointment in a patient with subacute cutaneous lupus erythematosus. J Dermatol Treat 2004;15:63-4.

26. Von Pelchrzim R, Schmook T, Friedrich M, Worm M. Efficacy of topical tacrolimus in the treatment of various cutaneous manifestations of lupus erythematosus. Int J Dermatol 2006;45:84-5.

27. Böhm M, Gaubitz M, Luger TA, Metze D, Bonsmann G. Topical tacrolimus as a therapeutic adjunct in patients with cutaneous lupus erythematosus. Dermatology 2003;207:381-5.