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2008, Number 4

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Med Cutan Iber Lat Am 2008; 36 (4)

Sarcoidosis. A global approach

Gatti CF, Prahl P, Troielli P, Schroh R

Language: Spanish
References: 57
Page: 165-182
PDF size: 674.88 Kb.


ABSTRACT

Sarcoidosis is a multisystemic disease of unknown cause that frequently appears with bilateral hiliar adenopathy, lung infiltration and skin and eye lesions.
Diagnosis is made when clinical and radiological findings are backed by histopathology evidencing granulomas no caseosos of epitelial cells.
Predisposition to acquire sarcoidosis seems to be genetic, however only a small group of alelos de HLA could be identified in association to disease susceptibility.
Sarcoidosis is a syndrome that can obey to many precipitant factors. Some people think that there is only one antigenic agent, not identified yet, that conditions the involution or persistence of the disease, for reasons that are an enigma and a cause of intense research.
It has been described different skin manifestations settling a range of multiple and variable lesions. Even more relevant systemic manifestations have been described.
There is a special reference of diseases associated with sarcoidosis such as autoinmune pathology and hematological neoplasias.
The most used alternative therapies are cortocoesteroids and antimalarials.The methotrexate, thalidomide, tetracyclines and the infliximab are indicated in some special cases.


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