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ISSN 0210-5187 (Electronic)

2008, Number 3

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Med Cutan Iber Lat Am 2008; 36 (3)

Cutaneous angiosarcomas

Morales GV, Armario HJC, Fernández VJM

Language: Spanish
References: 20
Page: 146-151
PDF size: 309.13 Kb.


ABSTRACT

Angiosarcomas are rare malignant neoplasms originated from the endothelial cells of blood vessels. They can arise either on skin or in internal organs such as liver, breast, spleen or heart. Two cases of cutaneous angiosarcoma with different clinical and evolution are reported.
The first case is a 65 years old male with a violaceous plaque on the nasal dorsum, infiltrate to palpation and with a 7 months evolution . The dermatopathological study showed a proliferation of irregular dissecting and anastomosed vessels, that infiltrated the underlying skeletal muscle. Atypical endothelial cells with big and hyperchromatic nucleus and abundant mitosis could be observed in great detail. Tumour cells were positive to CD31. The treatment consisted on a wide removal of the lesion, repairing with glabella flap and radiotherapy on the intervened area. After a year long follow up, no persistence was observed.
The other case was a 78 years old female with a big ulcerated tumour located on the left frontoparietal area. It presented an excrescent mass, ulcerated, friable, with points of necrosis and clear signs of tumour proliferation. The dermato-pathological study was analogous to the case above. The big size of the tumour made it not suitable for removal, therefore we sent the case to the Oncology Service to receive palliative treatment with chemotherapy. However, we could only achieve the slow down of the tumour progress, but finally the patient dead.


REFERENCES

  1. Caldwell JB, Ryan MT, Beson PM, James WD. Cutaneous angiosarcoma arising in the radiation site of a congenital hemangioma. J Am Acad Dermatol 1995;865-70.

  2. Rao J, DeKoven JG, Beatty JD, Jones G. Cutaneous angiosarcoma as a delayed complication of radiation therapy for carcinoma of the breast. J Am Acad Dermatol 2003;49:532-8.

  3. Stewart FW, Treves N. Lymphangiosarcoma in postmastectomy lymphedema. Cancer 1948;64-81.

  4. Sánchez JL, Ackerman AB. Trastornos inflamatorios y neoplásicos de la dermis. En: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen FK (EDS). Dermatología en medicina general. 4ª edición. Nueva York: McGraw-Hill, 1993:1296-9

  5. Repiso B, Pérez-Gil A, Argueta O, Ríos JJ, Sotillo I, Camacho F. Angiosarcoma de cara y cuero cabelludo. A propósito de un caso. Actas Dermosifilogr 1999;90:104-8.

  6. Sturgis EM, Potter BO. Sarcomas of the head and neck region. Curr Opin Oncol 2003;15:239-52.

  7. Kibe Y, Kishimoto S, Katoh N, Yasuno T, Yasumura T, Oka T. Angiosarcoma of the scalp associated with renal transplantation. Br J Dermatol 1997;136:752-6.

  8. Águila LI, Sánchez JL. Angiosarcoma of the face resembling rhinophyma. J Am Acad Dermatol 2003;49:530-1.

  9. Gallardo MA, Bosch RJ, Vidal L, Cabra B, Rodrigo AB, De Gálvez MV, Herrera E. Angiosarcoma arising on rhynophyma. Eur J Dermatol 2000;10:555-8.

  10. Lydiatt WM, Shaha AR, Shah JP. Angiosarcoma of the head and neck. Am J Surg 1994;168:451-4.

  11. Strutton G. Tumores vasculares. En: Weedon D (EDS). Piel patología. Edición en español. Madrid: Marbán, 2002:846-7.

  12. Lever WF. Tumores del tejido vascular. En: Lever WF, Schaumburg-Lever G (EDS). Histopatología de la piel. 5ª edición. Buenos Aires: Intermédica, 1979:537-40.

  13. Nishiwaki Y, Tada Y, Nakatani C, Yamashina Y, Shirai T, Miyagawa S. A case of angiosarcoma of the nose. J Dermatol 2002;29:593-8.

  14. Bullen R, Larson PO, Landeck AE, Nychay S, Snow SN, Hazen P et al. Angiosarcoma of the head and neck managed by a combination of multiple biopsies to determine tumor margin and radiation therapy. Report of three cases and review of the literature. Dermatol Surg 1998;24:1105-10.

  15. Marwan F, Defrances MC, Ohori NP, Ramanathan, RK. Unusual tumors involving the head and neck region: case 1. Angiosarcoma of the scalp. J Clin Oncol 2001;19:4173-4.

  16. Casper ES, Waltzman RJ, Schwartz GK, Sugarman A, Pfister D, Ilson D et al. Phase II trial of paclitaxel in patients with soft-tissue sarcoma. Cancer investigation 1998;16:442-6.

  17. Fata F, O’Reilly E, Ilson D, Pfister D, Leflel D, Kelsen DP et al. Paclitaxel in the treatment of patients with angiosarcoma of the scalp of face. Cancer 1999;86:2034-7.

  18. Spieth K, Gille J, Kaufmann R. Therapeutic efficacy of interferon alfa-2a and 13-cis-retinoic acid in recurrent angiosarcoma of the head. Arch Dermatol 1999;135:1035-7.

  19. Martínez JA, Pujol C. Tumores vasculares malignos de la piel. Piel 1995;10:235-43.

  20. Pérez-España L, Pajares G, López R, Sigüenza M. Angiosarcoma cutáneo. Formación médica continuada 2001;8:655.




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