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1999, Number 4

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Rev Inst Nal Enf Resp Mex 1999; 12 (4)

Laryngeal amyloidosis: One case.

Mena GAL, Ramírez GA, Soda MA, Rivera RRM

Language: Spanish
References: 10
Page: 281-283
PDF size: 239.94 Kb.


ABSTRACT

Amyloidosis is an uncommon disease characterized by deposits of monoclonal light-chain fibrillar immunoglobulin aggregates in vital organs. It may be localized or generalized, and primary or secondary. Various organs may be involved. It is a rare entity in head and neck and appears in localized form in 12 to 90% of the cases, the larynx being the most common. The present study describes the case of a female patient of 62 years of age with hoarseness of 1 -year evolution. Physical examination only revealed pink, rugged lesions in the larynx, with involvement of false and true vocal cords, epiglottis and amyloid deposits above the vocal cords. The patient was treated with conventional direct microlaryngoscopy and biopsies to resect abnormal structures. The histological diagnosis reported laryngeal amyloidosis stained with Congo red. Systemic amyloidosis was discarded since all other studies were negative. A review of the literature on clinical, histopathological, diagnostic and therapeutic aspects of laryngeal amyloidosis is presented.


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