Delgado-Hachmeister JE, Rangel-Frausto MS, Ponce LS

Language: Spanish
References: 22
Page: 69-75
PDF size: 96.43 Kb.

ABSTRACT

Transmissible spongiform encephalopathies (TSE) are a group of diseases which have received a lot of attention in recent years. The interest on these diseases has been stimulated by the appearance of bovine spongiform encephalopathy (BSE) and the new variant of Creutzfeldt-Jakob disease (nvCJD); the latter is likely to be acquired by ingesting contaminated beef. Until now 109 cases of nvCJD have been reported, most of them occurring in the United Kingdom. Some experts think that this is the beginning of a nvCJD pandemic. Deep knowledge of the mechanisms of transmission of TSE is needed to prevent the emergence of a TSE pandemic in humans. We address various aspects of TSE and discuss prevention methods of TSE in ruminants and humans.

REFERENCES

1. Zeidler M, Stewart GE, Barraclough CR, Bateman DE, Bates D, Burn DJ et al. New variant Creutzfeldt-Jakob disease: Neurological features and diagnostic tests. Lancet 1997;350:903-907.

2. Collinge J, Sidle KCL, Meads J, Ironsidce J, Hill AF. Molecular analysis of prion strain variation and the aetiology of ‘new variant’ CJD. Nature 1996;383:685-690.

3. Office International des Epizooties. Organisation mondiale de la santé animale. Number of reported cases of bovine spongiform encephalopathy (BSE) world wide (excluding the United Kingdom). Switzerland. Updated 06.08.2001. Disponible en: http://www.oie.int/info/en_esbmonde.htm

4. Prusiner SB. Prion diseases and the BSE crisis. Science 1997;278:245-251.

5. Prusiner SB. The prion diseases. Sci Am 1995;268:48-57.

6. Telling GC, Collinge J. Transmissible spongiform encephalopathies of humans and animals. En: Infect Dis. Armstrong D, ed. Essex Mosby 1999: 19.1-19.6

7. Collinge J, Palmer MS, Dryden AJ. Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease. Lancet 1991;337:1441-1442.

8. Weissmann C. The ninth datta lecture: Molecular biology of transmissible spongiform encephalopathies. FEBS Lett 1996;389:3-11.

9. Manuelidis L. The dimensions of Creutzfeldt-Jakob disease. Transfusion 1994;34:915-928.

10. Dickinson AG, Outram GW. Genetic aspects of unconventional virus infections: The basis of the virino hypothesis. Ciba Found Symp 1988;135:63-83.

11. Prusiner SB. Nobel lecture: Prions. Proc Natl Acad Sci 1998;95:13363- 13383.

12. Haywood AM. Transmissible spongiform encephalopathies. N Engl J Med 1997;337:1821-1828.

13. Prusiner SB. Prions and neurodegenerative diseases. N Engl J Med 1987;317:1571-1581.

14. Gajdusek DC. Unconventional viruses and the origin and disappearance of kuru. Science 1977;197:943-960.

15. Brown P, Preece MA, Will RG. “Friendly fire” in medicine: Hormones, homografts, and Creutzfeldt-Jakob disease. Lancet 1992;340:24-27.

16. Will RG, Ironside JW, Zeidler M, Cousens SN, Estibeiro K, Alperovitch A et al. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 1996;347:921-925.

17. Department of Health. Monthly Creutzfeldt-Jakob Disease Statistics. 2001/0369. Monday 6th August 2001. United Kingdom. Disponible en: http://www.doh.gov.uk/cjd/stats/aug01.htm.

18. Ghani AC, Ferguson NM, Donnelly CA, Anderson RM. Predicted vCJD mortality in Great Britain. Nature 2000;406:583-584.

19. Cousens SN, Vynnycky E, Zeidler M, Will RG, Smith PG. Predicting the CJD epidemic in humans. Nature 1997;385:197-198.

20. WHO infection control guidelines for transmissible spongiform encephalopathies: Report of a WHO Consultation. Ginebra: WHO/CDS/ CSR/APH/2000.3, March 23-26, 1999. Disponible en: http://www.who.int/ emc/diseases/bse/.

21. Houston F, Foster JD, Chong A, Hunter N, Bostock CJ. Transmission of BSE by blood transfusion in sheep. Lancet 2000;356:999-1000.

22. Brown P, Will RG, Bradley R, Asher DM, Detwiler L. Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: Background, evolution, and current concerns. Emerg Infect Dis 2001;7:6-16.