Álvarez CO, Martínez MA, Quijano OF, Padilla LR

Language: Spanish
References: 31
Page: 19-29
PDF size: 211.04 Kb.

ABSTRACT

Aim: Experimental study developed at the ABC Hospital, Mexico City, with the objective of confirming if a barrier of fibrin glue applied over an intraperitoneal mesh may diminish the adherence rate in a rat model. Material and method: Intraperitoneal implantation of 4 types of meshes with different amounts (100%, 50%, 26%, 0%) of polypropylene (PP) by laparotomy in the abdominal wall in two groups of Wistar rats, covering all the meshes in study one. The rats were re-operated by laparoscopy 15 days later, to verify the In Situ adherences and afterwards, all were explanted to determine the percentage of adherences covering the meshes. Statistical analysis: All data was analyzed with the “U” of Mann-Whitney. Results: We found an important reduction of the adherence rate with statistical significance over the meshes in the fibrin applied group, compared with the control one, no matter the amount of PP. Conclusion: In this experimental study a fibrin glue barrier was highly effective to diminish the adhesion formation over different kinds of meshes with IPOM technique, no matter the amount of PP of each one. This finding may have an important clinical application. We propose hypothesis to explain the possible mechanisms but further clinical studies are needed.

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