Incidence trends of hepatic tumors in childhood.

Juan Manuel Mejía-Aranguré; Olbeth Beutelspacher-Vázquez; Servando Juárez-Ocaña; José Vázquez-Langle; María del Carmen Martínez-García; Arturo Fajardo-Gutiérrez

2002, Number 2

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salud publica mex 2002; 44 (2)

Incidence trends of hepatic tumors in childhood.

Mejía-Aranguré JM, Beutelspacher-Vázquez O, Juárez-Ocaña S, Vázquez-Langle J, Martínez-García MC, Fajardo-Gutiérrez A

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Language: Spanish
References: 25
Page: 100-107
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ABSTRACT

Objective. To evaluate the incidence trends of hepatic tumors among children living in Mexico City. Material and Methods. A cross-sectional hospital survey was conducted to yield two databases. The first database contains the registry of all the cases of hepatic tumors occurring during the period 1982-1991, in public hospitals of Mexico City. The second database contains all hepatic tumor cases found between 1996 and 1999 in Hospital de Pediatría del Centro Médico Nacional “Siglo XXI” and in Hospital General del Centro Médico La Raza, both hospitals pertaining to Instituto Mexicano del Seguro Social (Mexican Institute of Social Security). The average annual incidence rates (AAIR) were calculated for each type of hepatic tumor. The rates were standardized with the direct method, using as standard the world population under 15 years of age. The trends were evaluated with the annual incidence rates and the average rate of change assuming a Poisson distribution. Results. The AAIR for hepatoblastoma during the period 1982-1991 was three times higher for men than for women, with a value of 0.6 x10⁶. The group of 1-4 years of age was the most affected. For hepatocarcinomas the AAIR was twofold for women (0.14) as compared to men. Between 1996-1999 the AAIR for hepatoblastoma was 5.11 in women and 1.85 in men. The age group with the highest rate was women under one year of age. The AAIR for hepatocarcinoma was 0.64 for males and 1.23 for females. The most affected age group was males aged 10 to 14 years. No significant upward or downward trend was found in the incidence of hepatoblastomas. A non-significant change rate of 10% was found for hepatocarcinoma. Conclusions. No significant trends were observed in the incidence of hepatic tumors in children of Mexico City aged under 15 years, during the periods 1982-1991 and 1996-1999.

REFERENCES

1.- Exelby PR, Filler RM, Gnosfeld JL. Liver tumor in children with particular reference to hepatoblastoma and hepatocellular carcinoma: American Academy of Pediatric Surgical Section Survey-1974. Pediatr Surg 1975;10:329-337.
2.- Perilongo G, Shafford EA. Liver tumors. Eur J Cancer 1999;35:963-968.
3.- Raney B. Hepatoblastoma in Children: A Review. J Pediatr Hematol Oncol 1997;19:418-422.
4.- Newman KD. Hepatic tumors in children. Sem Pediatr Surg 1997;6:38-41.
5.- Douglass EC. Liver tumors. Rudolph AM, Hoffman JIE, Rudolph CD, ed. Rudolph’s Pediatrics. 19th Edition. East Norwalk Connecticut: Appleton & Lange, 1991:1213-1215.
6.- Parkin DM, Stiller CA, Draper GJ. Bieber CA. The international incidence of childhood cancer. Int J Cancer 1988;42:511-520.
7.- Chen WJ, Lee JC, Hung WT. Primary malignant tumor of liver in infants and children in Taiwan. J Pediatr Surg 1988;23:457-461.
8.- Ross JA, Gurney JG. Hepatoblastoma incidence in the United States from 1973 to 1992. Med Pediatr Oncol 1988;30:141-142.
9.- Rivera-Luna R, Martínez-Guerrero G. The problem of childhood cancer in a developing country. Int Pediatr Assoc 1986;7:411-419.
10.- Salas-Martínez M. Tumores hepáticos. Neoplasisas malignas en los niños. México: Editorial Panamericana, 1988:3-16.
11.- Fajardo-Gutiérrez A, Mendoza-Sánchez H, Valdez-Martínez E, Mejía- Aranguré JM, Yamamoto-Kimura LT, Mejía Domínguez AM et al. Frecuencia de neoplasias malignas en niños atendidos en hospitales del Distrito Federal. Estudio multicéntrico. Bol Med Hosp Infant Mex 1996;53:57-66.
12.- Fajardo-Gutiérrez A, Mejía-Aranguré JM, Gómez-Delgado A, Mendoza- Sánchez H, Garduño-Espinosa J, Martínez-García MC. Epidemiología de las neoplasias malignas en niños residentes del Distrito Federal (1982- 1991). Bol Med Hosp Infant Mex 1995;52:507-516.
13.- Estève J, Benhamou E, Raymond L. Space Variations and group correlations. Statistical methods in cancer research. Descriptive Epidemiology of Childhood Cancer. Lyon, France: International Agency for Research on Cancer, 1994;IARC Publication No. 128:107-201.
14.- Schymura MJ, Kahn AR, Wolfgang PE. Hepatic tumors. Parkin DM, Kramárová E, Draper GJ, Masuyer E, Michaelis JM, Neglia J et al.International Incidence of Childhood Cancer. Vol II. IARC Scientific Publication. Lyon, France: International Agency for Research on Cancer 1998;Number 144:125-130.
15.- Sharp L, Cotton S, Little J. Descriptive epidemiology. En: Little J, ed. Epidemiology of childhood cancer. Lyon, France: International Agency for Research on Cancer, 1999;IARC Scientific Publications No. 149:10-16.
16.- Bulterys M, Goodman MT, Smith M, Buckley J. Hepatic Tumors. En: Ries LAG, Smith MA, Gurney JG, Linet M, Tamra T, Young JL et al eds. Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995, Bethesda, (MD): National Cancer Institute, SEER Program, 1999;NIH Pub. No. 99-44-49:91-98.
17.- Ikeda H, Matsuyama S, Tanimura M. Association between hepatoblastoma and very low birth weight: A trend or a chance? J Pediatr 1997;130: 557-560.
18.- Young JL, Miller RW. Incidence of malignant tumors in U.S. children. J Pediatr 1975;86:254-258.
19.- Iwama T, Mishima V. Mortality in young first degree relatives of patients with familiar adenomatous polyposis. Cancer 1994;73:2065-2068.
20.- Otten J, Smets R, De Jager R, Gerard A, Maurus R. Hepatoblastoma in an infant after contraceptive intake during pregnancy (letter). N Engl J Med 1977;297:222.
21.- Khan A, Bader JL, Hoy GR, Sinks LF. Hepatoblastoma in child with fetal alcohol syndrome. Lancet 1979;1:403-404.
22.- Melamed I, Bujanover Y, Hammer J, Spirer Z. Hepatoblastoma in an infant born to a mother after hormonal treatment for sterility (letter). N Engl J Med 1982;307:820.
23.- Buckley JD, Sather H, Ruccione K, Rogers PCJ, Haas JE, Henderson BE et al. A case-control study of risk factors for hepatoblastoma. Cancer 1989;64:1169-1176.
24.- Ishak KG, Glunz PR. Hepatoblastoma and hepatocarcinoma in infancy and childhood. Cancer 1967;20:396-422.
25.- Leuschner I, Harris D, Schmidt D. The association of hepatocellular carcinoma in childhood with Hepatitis B infection. Cancer 1988;62: 2363-2369.