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Instituto Nacional de Salud Pública

2003, Number S2

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salud publica mex 2003; 45 (S2)

Determining lead sources in Mexico using the lead isotope ratio

Chaudhary-Webb M, Paschal DC, Ting B, Elliot C, Hopkins H, Sanín LH, Ghazi MA

Language: English
References: 23
Page: 183-188
PDF size: 108.85 Kb.


ABSTRACT

Objective. Lead poisoning can, in some cases. be traced to a specific route or source of exposure on the basis of the individual's blood lead isotope ratio. To assess the major source of lead exposure among women residing in Mexico City, we compared blood, ceramic, and gasoline lead isotope ratios. Material and Methods. The study population, randomly selected from participants of a large trial, (1/1996-12/1996) comprised of 16 women whose lead levels exceeded 10 µg/dl and who reported using lead-glazed ceramics. Lead isotope ratios were performed on a Perkin Elmer 5000 Inductively Coupled Plasma Mass Spectrometer (ICP-MS) interfaced with a Perkin Elmer HGA-6OOMS Electrothermal Vaporization System (ETV). Results. The isotope ratios (206Pb/204Pb, 207Pb/204Pb, and 208Pb/204Pb) of both the blood specimens and their correspondin ceramic specimens were highly correlated. with r=0.9979, r2=0.9958, r= 0.9957, r2=0.9915 and r=0.9945, r2=0.9890 values for the three isotope ratios, respectively, suggesting that the lead exposure most likely resulted from the use of these ceramic, Measurements of lead isotope ratios from leaded gasoline in use at the time of blood sampling, differed from those in blood and ceramics. Conclusions. Determining lead isotope ratios can be an efficient tool to identify a major source of lead exposure and to support the implementation of public health prevention and control measures.


REFERENCES

  1. Romieu I, Palazuelos E, Hernández-Avila M, Ríos C, Muñoz I, Jiménezv C et al. Sources of lead exposure in Mexico City. Environ Health Perspect 1994;102:384-389.

  2. Hernández-Avila M. El plomo: un problema de salud pública en México. En: Hernández-Avila M, Palazuelos-Rendón E, ed. Intoxicación por plomo en México: prevención y control. Cuernavaca, Morelos, México: Instituto Nacional de Salud Pública, 1995; Perspectiva en Salud Pública 21:13-24.

  3. Sanín LH, González-Cossío T, Romieu I, Peterson KE, Ruiz S, Palazuelos E. Effects of maternal lead burden on infant weight and weight gain at one month of age among breastfed infants. Pediatrics 2001; 107:1016-1022.

  4. González-Cossío T, Peterson K, Sanín LH, Fisbein E, Palazuelos E, Aro A et al. Decrease in birth weight in relation to maternal bone-lead burden. Pediatrics 1997;100:1-7.

  5. Palazuelos-Rendón E. Effects of lead on children’s health. En: Howson CP, Hernández-Avila M, Rall DP, Ed. Lead in the Americas: A call for action. Cuernavaca, Morelos, México: National Institute of Public Health, 1995: 59-67.

  6. Inskip MJ, Franklin CA, Subramanian KS, Blenkinsop J, Wandelmaier F. Sampling of cortical and trabecular bone for lead analysis: Method development in a study of lead mobilization during pregnancy. Neurotoxicology 1992; 13:825-834.

  7. Russell RD, Farquhar RM. Lead isotopes in geology. Nueva York (NY), Interscience Publishers, 1960.

  8. Rabinowitz MB. Imputing lead sources from blood lead isotope ratios. En: Beard ME, Iske SDA, Ed. Lead in paint, soil, and dust: Health risks, exposure studies, control measures, measurement methods, and quality assurance, ASTM STP 1226. Filadelfia (PA): American Society for Testing and Materials, 1995: 63-75.

  9. Lieser KH, Fey W. Isotopic fingerprint method: Assessment of the origin of rare-earth compounds from the isotope ratios of lead impurities. Fresenius J Anal Chem 1995; 351:129-133.

  10. Chaudhary-Webb M, Paschal DC, Elliot WC, Hopkins HP, Ghazi AM, Ting BC et al. ICP-MS determination of lead isotope ratios in whole blood, pottery, and leaded gasoline: Lead sources in Mexico City. Atomic Spectroscopy 1998; 19:156-163.

  11. Fassel VA. Quantitative elemental analyses by plasma emission spectroscopy. Science 1978;202:183-191.

  12. Faure G. Principles of isotope geology. Nueva York (NY): 1986: 227-247.

  13. Ghazi AM. Lead in archaeological samples: An isotopic study by ICP-MC. Appl Geochem 1994; 9:627-636.

  14. Hernández-Avila M, Romieu I, Ríos C, Rivero A, Palazuelos E. Leadglazed ceramic as major determinants of blood lead levels in Mexican women. Environ Health Perspect 1991; 94:117-120.

  15. Morrison DF. Multivariate statistical methods. 3a. Ed., Pennsylvania: Ed. Mc Graw-Hill, 1990:177-178.

  16. Romieu I, Carreón T, López L, Palazuelos E, Ríos C, Manuel Y et al. Environmental urban exposure and blood lead levels in children of Mexico City. Environ Health Perspect 1995; 103:1036-1040.

  17. Rothenberg SJ, Schnaas L, Perroni E, Hernández RM, Karchmer S. Secular trend in blood lead levels in a cohort of Mexico City children. Arch Environ Health 1998; 53:231-235.

  18. Fernández GO, Martínez RR, Fortoul TI, Palazuelos E. High blood lead levels in ceramic folk art workers in Michoacan, Mexico. Arch Environ Health 1997; 52:51-55.

  19. Ketterer ME. Assessment of overall accuracy of lead isotope ratios determined by inductively coupled plasma mass spectrometry using batch quality control and the Youden two-sample method. J Anal At Spectrom 1992; 7:1128-1129.

  20. Delves HT, Campbell MJ. Measurements of total lead concentrations and of lead isotope ratios in whole blood by use of inductively coupled plasma source mass spectrometry. J Anal At Spectrom1998;3:343-348.

  21. Yaffe Y, Flessel CP, Wesolowski JJ, Del Rosario A, Guirguis GN, Matías V et al. Identification of lead sources in California children using the stable isotope ratio technique. Arch Environ Health 1983; 38:237-245.

  22. Hernández-Avila M, Sanín LH, Romieu I, Palazuelos E, Tapia-Conyer R, Oláiz G et al. Higher milk intake during pregnancy is associated with lower maternal and umbilical cord lead levels in postpartum women. Environ Res 1997; 74:116-121.

  23. Lacasaña-Navarro M, Romieu I, Sanín-Aguirre LH, Palazuelos-Rendón E, Hernández-Avila M. Consumo de calcio y plomo en mujeres en edad reproductiva. Rev Invest Clin 1996;48:425-430.




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