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ISSN 0016-3813 (Print)

2008, Number 2

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Gac Med Mex 2008; 144 (2)

Estudio de asociación y metaanálisis del gen de la apolipoproteína E y esquizofrenia

Tovilla-Zárate C, Camarena B, Apiquian R, Nicolini H

Language: Spanish
References: 37
Page: 79-83
PDF size: 101.02 Kb.


ABSTRACT

Background: Schizophrenia is a mental disorder of unknown etiology. Epidemiological, association and linkage studies suggest the presence of genetic factors in the development of this disorder. Numerous studies have been undertaken to gain insight on the role of the ApoE gene in schizophrenia. However, findings remain controversial.
Objective: The current study analyzed the ApoE gene among schizophrenic patients of Mexican origin.
Results and conclusions: No significant differences were found in the distribution of alleles (χ2=0.94, df=2, p=0.62), or genotypes (χ2=1.02, df=2, p=0.59). The meta-analysis comprising 19 association studies (including the present one) showed that the risk allele ε4 of ApoE is not associated with the development of schizophrenia (OR 1.04, CI 95%=0.90-1.21, p=0.184) in the absence of heterogeneity (χ2=18.8, df=18, p=0.4).


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