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2008, Número 2

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Gac Med Mex 2008; 144 (2)


Estudio de asociación y metaanálisis del gen de la apolipoproteína E y esquizofrenia

Tovilla-Zárate C, Camarena B, Apiquian R, Nicolini H

Idioma: Español
Referencias bibliográficas: 37
Paginas: 79-83
Archivo PDF: 101.02 Kb.


RESUMEN

Antecedentes: La esquizofrenia es una enfermedad mental cuyas causas etiológicas son desconocidas. Los estudios de epidemiología genética, de asociación y de ligamiento, han sugerido la presencia de factores genéticos involucrados en el desarrollo de la esquizofrenia. Existen numerosos estudios dirigidos a comprender la participación del gen de la apolipoproteína E (ApoE) en la esquizofrenia, sin embargo, los resultados son controversiales por la falta de replicación de los hallazgos.
Objetivo: Para conocer el efecto del alelo ε4 de ApoE en esquizofrenia, se analizó la frecuencia de genotipos y alelos de ApoE en pacientes de origen mexicano.
Resultados y conclusiones: No observamos diferencias estadísticamente significativas en los pacientes con esquizofrenia comparados con el grupo control en las frecuencias por alelos (χ2=0.94, gl=2, p=0.62) ni por genotipos (χ2=1.02, gl=2, p=0.59). Finalmente, el metaanálisis de 19 estudios de asociación, incluyendo el presente estudio, mostró que el alelo de riesgo ε4 de ApoE no está asociado con el desarrollo de la esquizofrenia (OR=1.04, IC 95%=0.90-1.21, p=0.184), sin la presencia de heterogeneidad (χ2=18.8, gl=18, p=0.4).


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