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Instituto Nacional de Salud Pública

2003, Number 4

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salud publica mex 2003; 45 (4)

Hyperthyrotropinemia in Mexican newborns

Vela-Amieva M, Hernández-Osorio C, Gamboa-Cardiel S, González-Contreras CR, Pérez-Andrade ME, Ortiz-Cortés J, Aguirre-Vélez BE

Language: Spanish
References: 44
Page: 269-275
PDF size: 119.05 Kb.


ABSTRACT

Objective. To assess the differences in the blood concentration levels of the thyroid stimulating hormone and their possible use as an indicator of iodine sufficiency, in a sample of Mexican newborns. Material and Methods. A crosssectional study was conducted from September 1999 to August 2000, among 25,427 Mexican newborns in the Ministry of Health clinics from 5 states. A total of 8 095 heel-prick and 17 332 umbilical cord blood samples were analyzed. Blood samples were collected in filter paper and processed by enzyme-linked immunosorbent assay. The Mann-Whitney U test and the Kruskal-Wallis test were used for statistical analyses. Results. Hyperthyrotropinemia was found in 9.95% of heel samples and in 24.27% of umbilical cord samples (TSH›5 µUI/ml). Conclusions. The percentage of hyperthyrotropinemia observed in this study was higher than that expected in a population with sufficient iodine intake; these findings could be due to poor maternal iodine intake.


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