2008, Number 1
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Gac Med Mex 2008; 144 (1)
La resistencia a los antifúngicos:un problema emergente en México
Manzano-Gayosso P, Méndez-Tovar LJ, Hernández-Hernández F, López-Martínez R
Language: Spanish
References: 24
Page: 23-26
PDF size: 45.20 Kb.
ABSTRACT
Background: An increase in mycosis associated with therapeutic failure has been observed worldwide. The dearth of data in Mexico led us to study antifungal resistance.
Material and methods: Seventy six isolates of patients from the Hospital de Especialidades, Centro Médico Nacional Siglo XXI,Instituto Mexicano del Seguro Social were included: 36 with dermatophytoses and 40 with candidiasis. Dermatophytes were assesed using the E-test method and Candida spp. using the brothmicro dilution method. Antifungal drugs included itraconazole, ketoconazole and fluconazole for dermatophytes; in addition, voriconazole and amphotericin B were used to treat yeasts.
Results: From the 36 dermatophytes, seven isolates (19.4%) showed resistance to one or more antifungal drugs: three to Trichophytonrubrum, three to T. mentagrophytes and one to T. tonsurans. One T. rubrum isolate was resistant to the three azoles; the other six isolates were resistant to fluconazole only. From the 40 Candida isolates, 11 (27.5%) showed resistance: seven to ketoconazole and itraconazole; three only to itraconazole and one to ketoconazole. One C. glabrata isolate showed resistance to the four azoles. None of the yeasts showed resistance to amphotericin B.
Conclusion: Therapeutic failure could be caused by drug resistance. In our study we found an antifungal resistance of 20% and 27.5% in dermatophytes and in yeasts respectively.
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