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2007, Number 4

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Vet Mex 2007; 38 (4)

Stem cells and embryonic stem cells: Biological differences

Dolly Macías Riveros, Juan Carlos Vázquez Chagoyán, Rogelio Alonso Morales, Marco Cajero Juárez

Language: English/Spanish
References: 77
Page: 477-501
PDF size: 586.36 Kb.


ABSTRACT

The stem cells have been classified in three types according to their natural niche of origin, aptitude and differential function: totipotential, pluripotential and multipotential; the first, called embryonic stem cells (ES) originate from the morulae; the second, come from the inner cell mass of the blastocyst (ICM); and the third, known as multipotent adult progenitor cells (MAPC) are found in some adult tissues. The biological difference lies in their capabilities to produce cell lines, the totipotentials have the faculty to originate a complete organism, the pluripotential can generate all the cellular types and even the germinal line and the multipotentials can derivate in specific lineages. The stem cells are able to self-renew, and originate daughter-cells compromised with certain development routes; they are characterized for their indefinite division and are morphologically and functionally differentiated. When the stem cells and some progenitor types are extracted from their natural environment and are grown in vitro, in suitable medium, can be transfected and remain in an undifferentiated state without losing their potentiality; thus, when they are reintegrated to blastocyst receptors they are able to go on with their development. The study and compilation of information about these biological qualities of differential function, as well as their usefulness in homologous recombination and production of animal models that generate recombinant proteins, applicable for preventive-regenerating medicine and treatment of diseases, constitute the aim of this work.


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