1998, Number 3
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Med Crit 1998; 12 (3)
Comparative study with low-dose dobutamine and low-dose dopamine in the management of renal failure of the critically ill patient
Lara GBM, Rosas GA, Cervantes OP
Language: Spanish
References: 15
Page: 79-83
PDF size: 114.16 Kb.
ABSTRACT
Objective. To compare the changes in renal function during infusions of low-dose dobutamine/dopamine in abdominal sepsis patients with kidney dysfunction.
Design. Case series, prospective study.
Setting. ICU of a general hospital of Tijuana, Mexico.
Patients and methods. Twenty five patients (mean age 47 ± 9 years) with abdominal sepsis.
Interventions. Dobutamine and dopamine infusions (3.1 µg/kg/min) were sequentally administered over 72 hours in two stages.
Measurements and main results. Hemodynamic values, hourly diuresis and 24-hour creatinine clearance (Ccr) were measured during the last 24 hours of each infusion. Dobutamine increased Ccr from 54 ± 12 (baseline value) to 60 ± 11 mL/min (first stage) and 66 ± 11 mL/min (second stage); p ‹ 0.001. Dopamine produced a diuresis of 80 ± 15 mL/h at the first stage and 84 ± 12 mL/min at the second stage, compared with baseline value (37 ± 7 mL/min); p ‹ 0.001. Dobutamine does not modified urine output at the two stages.
Conclusion. Dobutamine may be useful in the management of renal dysfunction in ICU patients with abdominal sepsis.
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