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1999, Number 1

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Med Crit 1999; 13 (1)

Methylene blue in refractory shock

Carrillo ER, Núñez MFN, Alvarado MC

Language: Spanish
References: 40
Page: 28-35
PDF size: 118.99 Kb.


ABSTRACT

Objective. To evaluate the usefulness of methylene blue in a septic shock patient.
Design. A case report and literature review.
Setting. An ICU of a tertiary care hospital of Mexico City.
Patient. A 75-year-old woman admitted to the ICU due to refractory shock.
Interventions. Mechanical ventilation, fluid administration, dobutamine, norepinephrine, methylene blue, antibiotics, invasive and non-invasive monitoring.
Measurements and main results. A 2 mg/kg dosage of methylene blue was administered intravenously over a 180 min. period and hemodynamics measurements were obtained at baseline and at 15, 30, 45, 60, 120 and 180 minutes. An increase of mean arterial pressure, cardiac index, systemic vascular resistance, oxygen delivery and diastolic function was observed. However, a progressive cardiovascular deterioration was observed later and the patient died.
Conclusion. Methylene blue improves transiently the hemodynamics of patients with septic shock.


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