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2008, Number 1

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Rev Mex Anest 2008; 31 (1)

Generating mechanisms and future therapeutic considerations of the painful diabetic neuropathy

Betancourt-Sandoval JA, Covarrubias-Gómez A, Guevara-López U

Language: Spanish
References: 55
Page: 28-36
PDF size: 164.85 Kb.


ABSTRACT

Painful diabetic neuropathy (PDN) is a chronic complication of diabetes mellitus (DM). The reported prevalence of DM in general population is 6.9% and the prevalence of PDN in diabetic patients ranges from 20 to 24%. Diabetic neuropathy is characterized by the presence of distal weakness, absence of tendinous reflexes, pain and loss of distal extremities sensitivity. These findings are the final result of a variety of mechanisms involves in its production therefore some authors suggests a mechanism-based pharmacologic approach. The main objective for the treatment of this disease is to control of serum-glucose concentration and pain. To achieve this goal, diverse drugs such as aldolase-reductase and serotonine re-uptake inhibitors, tricyclic antidepressants, anticonvulsivants, mexiletine, tramadol, levodopa, gamma-linolenic acid, alpha-lipolic acid, dextrametophan, capsaicine, transcutaneous electric nerve stimulation, acupuncture, among others had been used. For these reasons, our objective is to present to the reader updated information that may help in the identification, evaluation, and treatment of this disease.


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