Vera-Lastra OL, Medina-García G, Guadalupe-Reséndiz-Pérez L, Ángeles-Garay U, Torres-Ambriz P, Jara LJ

Language: Spanish
References: 40
Page: 471-475
PDF size: 55.78 Kb.

ABSTRACT

Objective: Assess the prevalence of hypothyroidism and antithyroglobuline antibodies (AbATg) among Mexican patients with systemic sclerosis (SSc).
Material and methods: Thyroid function was studied in SSs patients and controls. Triiodothyronine, thyroxine, thyroid stimulant hormone (TSH) and AbATg were measured.
Results: 110 SSc patients (106 women and 4 men), mean age 48.1 ± 28.5 yrs versus 80 healthy controls (76 women and 4 men) with mean age 47.5 ± 28.8 yrs were included. Hypothyroidism was diagnosed in 19% patients compared with 1.3% in the control group. The following results were found; triyodotironina: 82 ng/dl versus 160 ng/dl, p ‹ 0.000; tiroxina: 5.4 ng/dl versus 7 ng/dl, p ‹ 0.01; TSH: 8.2 µUl/ mL versus 1.1 ± 2 µUl/mL, p ‹ 0.000. Subclinical hypothyroidism was observed in 35% patients versus 0% controls, TSH: 7.2 µUl/ml versus 1.2 ± 1.4 µUl/ml, p ‹ 0.000; triyodotironina: 116 ng/dl compared with 160 ng/dl, p = ns; tiroxina: 7.0 ng/dl vs. 7.0 ng/dl, p ns; AbATg were positive in patients 54% and 2.5%, p ‹ 0.001 in the control group.
Conclusions: Our study reports a high prevalence of hypothyroidism among SSc Mexican patients, especially of the subclinical type. We need to consider hypothyroidism as a clinical entity often found among SSc patients, and start hormone replacment treatment accordingly.

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