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ISSN 0016-3813 (Print)

2007, Number 5

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Gac Med Mex 2007; 143 (5)

II. Participación del óxido nítrico en la fisiopatología cardiovascular

Pastelín-Hemández G, Valle-Mondragón L, Tenorio-López FA, Torres-Narváez JC

Language: Spanish
References: 21
Page: 406-408
PDF size: 62.93 Kb.


ABSTRACT

Nitric oxide, or nitrogen monoxide, as a chemical entity, was described during the 18th century. Its importance in biology, and particularly in medicine dates from the 1980’s. Nitric oxide harmonizes several biological functions within cells and tissues, and participates in a concerted and very important feedback with the cardiovascular system. Its chemical and biological properties, make nitric oxide a powerful paracrine and autocrine messenger with great capacity to regulate systemic arterial pressure, blood flow, homeostasis and other physiopatological actions such as systemic arterial hypertension. For these reasons, knowledge of nitric oxide biology has allowed the design of therapeutic cardiovascular system strategies. Protein regulation of nitric oxide synthases is a very recent finding that improves the understanding of endothelial dysfunction and can aid in the design of improved therapeutic resources.


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