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2007, Number 4

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Gac Med Mex 2007; 143 (4)

Evaluación del corregistro de imágenes de resonancia magnética y tomografía por emisión de positrones con 2-desoxy-2-flúor-d-glucosa marcada con flúor-18 en pacientes con patología tumoral cerebral

Ortega-López N, Mendoza-Vásquez RG, Adame-Ocampo G, Alexanderson-Rosas E, Cayetano-Alcaraz AA, Ángel-Celis M

Language: Spanish
References: 30
Page: 309-316
PDF size: 185.44 Kb.


ABSTRACT

Objective: To evaluate the role of PET and MRI fused image study in patients with primary brain tumors previously treated, to determine the presence of radionecrosis vs residual tumor viability.
Methods: Primary brain tumors were diagnosed by biopse and MR. 18FDG-PET scan and T1 enhanced MRI follow-up studies were performed between 3 and 5 months after treatment. The 18F-FDG uptake was semiquantitavively calculated by a region-of-interest based Tumor hotspot/ normal brain tissue index.
Results: Fifty-seven patients were studied, 37 had high grade gliomas; 9 had oligoastrocytomas; 5 had Embrionary tumors; 1 had a meningyoma and 1 had an oliodendroglial tumor. All MR studies showed tumor enhancement, without determine wether if it was radionecrosis or tumor viability. PET/MR fused study diagnosed 21 negative studies (30%) and 36 positive results (70%). Tumor hotspot/ normal brain tissue index correlated well with the visual analysis registered.
Conclusions: Visual analysis in the contrast enhanced MR overestimates the tumoral area, without defining a possible diagnosis between tumor viability and radionecrosis. Metabolic activity in the 18F-FDG PET study in the enhanced area, determines the presence of residual tumor viability. Therefore, coregistration can be used to obtain a more specific diagnosis optimizing the cinical use.


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