Ramírez RR, Núñez LJJ, Nevárez GAM

Language: English/Spanish
References: 19
Page: 321-325
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Induced Arthus reaction in the rabbit. lung has been proposed as a mechanism of tisular damage that could occur in some important pneumonias of domestic animals. The objective of this experiment was to pro voke an Arthus reaction in the lung of pigs in order to compare the lesions induced with those natural presentations in the main exudative pneumonias of swine. Ten animals, mixed breed, weighting 10 kg, were used for this purpose; nine out of them were included in three experimental groups, while one served as the control. The pigs included in the groups received ovalbumin with hidroxide aluminium as adjuvant by subcutaneous route. The control received a saline solution. Group A received 4 mg, group B, 16 mg, and group C, 32 mg of ovalbumin twice, 14 days apart. The animals were challenged at day 28 by endotracheal route employing 8, 32 and 80 mg of ovalbumin, respectively. The control animal received a saline solution endotracheally. All of them were sacrificed 12 hours after challenge. Post mortem examination showed congestion and mild lung edema in several animals included in groups B and C. Microscopically, allanimals in the experimental groups showed an interstitial pneumonia characterized by mild alveolar edema with moderate polymorphonuclear interstitium infiltration. There was no consolidation nor evident polymorpho nuclear exudation. Lesions were more obvious in animals belonging to groups B and C. The control did not show any changes. Although compatible with an Arthus reaction in the lung, these lesions resulted mild in comparison with those reported in the rabbit. These results do not support the hypothesis that an Arthus reaction related mechanism, could have the main role during the naturally occurring exudative pneumonias of swine.

REFERENCES

1. Armed Forces Institute of Pathology: Manual of Histology Staining Methods. 3rd ed. McGraw-Hill, New York, 1986.

2. Dungworth, D.L.: The respiratory system. In: Pathology of Domestic Animals. 3rd ed. Vol. 2. Edited by: Jubb, K.V.F., Kennedy, P.C., Palmer, N., 492-493. Academic Press, San Diego, California, 1985.

3. Emancipator, S.N. and Lamm, M.E.: Pathways of tissue injury initiated by humoral immune mechanisms. Lab. Invest., 54: 475-478 (1986).

4. Farrington, D.O.: Pneumonic pasteurellosis. In: Diseases of Swine. 6th ed. Edited by: Leman, A.D., Straw, B., Glock, R.D., Mengeling, W.L., Penny, R.H.C., Scholl, E., 436-444. Iowa State University Press, Ames, Iowa, 1986.

5. Jones, T.C. and Hunt, R.D.: Veterinary Pathology. 5th ed. Lea and Febiger, Philadelphia, 1983.

6. Larsen, G.L., Parrish, D.A. and Henson, P.M.: Lung defense. The paradox of inflammation. Chest, 83 (Suppl.): 1-5 (1983).

7. Lien, D.C., Henson, P.M., Capen, R.L., Henson, J.E., Hanson, W.L., Wagner, W.W. and Worthen, G.S.: Neutrophil kinetics in the pulmonary microcirculation during acute inflammation. Lab. Ivest., 65: 145-159 (1991).

8. Liggett, A.D., Harrison, L.R. and Farrell, R.L.: Acute inflammatory effects of intratracheally instilled Escherichia coli endotoxin and sonicated suspension of Haemophilus pleuropneu moniae in swine. Can. J. vet. Res., 50: 526-531 (1986).

9. Nicolet, J.: Haemophilus infections. In: Diseases of Swine. 6th ed. Edited by: Leman, A.D., Straw, B., Glock, R.D., Mengeling, W.L., Penny, R.H.C., Scholl, E., 426-436. Iowa State University Press, Ames, Iowa, 1986.

10. Pijoan, C.: Neumonía del cerdo. En: Avances en Enfermedades del Cerdo, 1985. Editado por: Morrilla, A., Correa, P., Stephano, A., 437-451. Asociación Mexicana de Veterinarios Especialista en Cerdos, México, D.F., 1985.

11. Ramírez-Romero, R., Rodríguez-Tovar, L.E. y Rivas-Farías, M.: Cronología del daño tisular mediado por un fenómeno semejante a la reacción de Arthus activa en el pulmón del conejo. Vet. Méx., 20: 169-178 (1989).

12. Ramírez-Romero, R., Rosales-García, F., Rodríguez-Tovar, L.E. y Rodríguez-Garza, A.P.: Daño neumónico provocado por Pasteurella multocida en conejos previamente sensibilizados con una bacterina homóloga y su relación con la reacción de Arthus. Vet. Méx., 21: 149-157 (1990).

13. Ramírez-Romero, R., Sandoval-Tassinari, D. y Suárez-Semour A.: Inducción de la reacción de Shwartzman en el pulmón de conejo empleando lipopolisacárido de Pasteurella multocida. Vet. Méx., 22: 415-424 (1991).

14. Slauson, D.O.: The mediation of pulmonary inflammation injury. Adv. vet. Sci. comp. Med., 26: 99-153 (1982).

15. Till, G.O., Morganroth, R.K. and Ward, P.A.: Activation of C5 by cobra venom factor is required in neutrophil-mediated lung injury in the rat. Am. J. path., 129: 44-53 (1987).

16. Warren, J.S., Barton, P.A. and Jones, M.L.: Contrasting roles for tumor necrosis factor in the pathogeneses of IgA and IgG immune complex injury. Am. J. Path., 138: 581-590 (1991).

17. Warren, J.S., Johnson, K.J. and Ward, P.A.: Immunoglobulin and complement-mediated immune injury. In: The Lung. Vol. 2. Edited by: Crystal, R.G., West, J.B., 1939-1946. Raven Press, New York, 1991.

18. Warren, J.S., Yabroff, K.R., Remick, D.G., Kunkel, S.L., Chensue, S.W., Kunkel, R.G. Johnson, K.J. and Ward, P.A.: Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat. J. Clin. Invest., 84: 1873-1882 (1989).

19. Yoshizawa, Y., Tanque, M., Yano, H., Sato, T., Ohtsuka, M., Hasegawa, S. and Kimula, Y.: Sequential changes in lung injury induced by preformed immune complexes. Clin. Immunol. Immunopath., 61: 376-386 (1991).