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2007, Number 3

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Vet Mex 2007; 38 (3)

Evaluation of different immunogens against bovine tuberculosis based on presence of lesions at necropsy

González SD, Díaz OF, Jaramillo ML, Pérez GR, Padilla UJ, Santillán FMA, Arriaga DC, Bojórquez NL

Language: English/Spanish
References: 62
Page: 271-284
PDF size: 276.11 Kb.


ABSTRACT

El objetivo de este trabajo fue comparar en becerras el grado de protección de tres inmunógenos contra la tuberculosis bovina, mediante las lesiones en la necropsia, ante un desafío con cepa patógena de M. bovis. Se utilizaron 24 becerras negativas a tuberculosis, divididas en cuatro grupos; el grupo 1 se vacunó con extracto proteínico de fi ltrado de cultivo (CFPE) de M. bovis; el grupo 2, con CFPE más interferón gamma (IFN-γ); el grupo 3, con BCG; el grupo 4 quedó como testigo. A los seis meses posvacunación, los animales se desafi aron con cepa de M. bovis. Posteriormente, a los seis meses se sacrifi caron, para evaluar la presencia de lesiones. En la necropsia, los linfonodos parecían abscesos; en la histopatología, las lesiones se defi nieron como una linfadenitis piogranulomatosa. Todos los animales del grupo testigo presentaron lesiones de tuberculosis, fue el grupo con mayor número de lesiones; 66.6% de éstas fueron severas. En los tres grupos inmunizados hubo animales que no presentaron lesiones; en los que si hubo, las lesiones fueron leves y moderadas. Ninguno de los esquemas de vacunación previno al 100% la infección, pues en todos los grupos hubo lesiones. Sin embargo, es evidente que en los grupos inmunizados hubo diferentes grados de protección, manifestados en ausencia de lesiones y disminución en el grado de severidad, en el grupo inmunizado con BCG esta disminución fue mayor. Se concluye que la vacuna BCG fue el inmunógeno que presentó mejores resultados, por ello podría utilizarse para el control de la tuberculosis en zonas de alta prevalencia.


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