medigraphic.com
A partir del año 2010, la Revista Oficial del INER cambió a NCT (Neumología y Cirugía de Tórax)

 Ver actualización

2004, Number 4

<< Back Next >>

Rev Inst Nal Enf Resp Mex 2004; 17 (4)

Immunological aspects of aging.

Sada-Ovalle I, Gorocica RP, Lascurain LR, Zenteno GE

Language: Spanish
References: 60
Page: 293-300
PDF size: 80.62 Kb.


ABSTRACT

Immunosenescence is a complex process involving multiple changes in lymphocyte subsets. In the elderly, these changes contribute to an increased incidence and severity of infectious diseases and some types of cancer. This paper reviews some of the immunological changes in the elderly and their association with certain diseases.


REFERENCES

  1. INEGI. Censo de Población y Vivienda del año 2000. (http://www.inegi.gob.mx/est/default.asp?c=2344).

  2. Harrison DE. Normal function of transplanted mouse erythrocyte precursors for 21 months beyond donor life spans. Nat New Biol 1972;237:220-222.

  3. Lansdrop PM, Dragowska W, Thomas TE, Little MT, Madani H. Age-related decline in proliferative potential of purified stem cell candidates. Blood Cells 1994;20:376-380.

  4. Geiger H, Van Zant G. The aging of lympho-hematopoietic stem cells. Nat Immunol 2002;3:329-333.

  5. Nilsson-Ehle H, Swolin B, Westin J. Bone marrow progenitor cell growth and karyotype changes in healthy 88-year-old subjects. Eur J Haematol 1995;55:14-18.

  6. Yu S, Abel L, Globerson A. Thymocyte progenitors and T cell development in aging. Mech Ageing Dev 1997;94:103-111.

  7. Stephan RP, Reilly CR, Witte PL. Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age. Blood 1998;91:75-88.

  8. Markert ML, Boeck A, Hale LP, Kloster AL, McLaughlin TM, Batchvarova MN, et al. Transplantation of thymus tissue in complete DiGeorge Syndrome. N Engl J Med 1999;341:1180-1189.

  9. Phyllis JL, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol 2004;5:133-139.

  10. Ceredig R, Rolink TA. A positive look at double-negative thymocytes. Nat Rev Immunol 2002;2:2-10.

  11. Haynes BF, Market ML, Sempowski GD, Patel DD, Hale LP. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol 2000;18:529-560.

  12. Fagnoni FF, Vescovini R, Passeri G, Bolonga G, Pedrazzoni M, Lavagetto G, et al. Shortage of circulating naive CD8 (+) T cells provides new insights on immunodeficiency in aging. Blood 2000;95:2860-2868.

  13. De Rosa SC, Herzenberg LA, Roederer M. 11-color,13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T cell receptor diversity. Nat Med 2001;7:245-248.

  14. Kong FK, Chen CL, Six A, Hockett RD, Cooper MD. T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool. Proc Natl Acad Sci USA 1999;96:1536-1540.

  15. Poulin JF, Viswanathan MN, Harris JM, Komanduri KV, Wieder E, Ringuette N. Direct evidence for thymic function in adult humans. J Exp Med 1999;190: 479-486.

  16. Stuling T, Maczek C, Bock G, Majdic O, Wick G. Reference intervals for human peripheral boold lymphocyte subpopulations from healthy young and aged subjects. Int Arch Allergy Immunol 1995;108:205-210.

  17. Grossman A, Maggio-Price L, Jinneman JC, Rabinovitch PS. Influence of aging on intracellular free calcium and proliferation of mouse T-cell subsets from various lymphoid organs. Cell Immunol 1991;135:118-131.

  18. Posnett DN, Sinha R, Kabak S, Russo C. Clonal population of T cells in normal elderly humans: the T cell equivalent to “benign monoclonal gammapathy”. J Exp Med 1994;179:609-618.

  19. Boucher N, Defeu-Duchesne T, Vicaut E, Farge D, Effros RB, Schachter F. CD28 expression in T cell aging and human longevity. Exp Gerontol 1998;33:267-282.

  20. Batliwalla FM, Rufer N, Lansdrop PM, Gregersen PK. Oligoclonal expansions in the CD8(+)CD28(-) T cells largely explain the shorter telomers detected in this subset: analysis by flow FISH. Hum Immunol 2000;61:951-958.

  21. LeMaoult J, Szabo P, Weksler ME. Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol Rev 1997;160:115-126.

  22. Thomsen O, Kettel K. Die sturke der menschlichen isoagglutninne und entsperchenden. Blutkorperperchenrezeptoren im vershiedenenen. Lebensatern 2 Immunitatsforsch 1929;63:67-93.

  23. Baumgartner L. Age and antibody production: Qualitative changes in antisera associated with aging. J Immunol 1934;27:407-416.

  24. Schwab R, Walters CA, Weksler ME. Host defense mechanisms and aging. Semin Oncol 1989;16:20-27.

  25. Weksler ME. Changes in the B-cell repertoire with age. Vaccine 2000;18:1624-1628.

  26. Hallgren HM, Buckley CE, Gilbertsen VA, Yunis EJ. Lymphocyte Phytohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans. J Immunol 1973;111:1101-1107.

  27. Nobrega A, Haury M, Gueret R, Coutinho A, Weksler ME. The age-associated increased in autoreactive immunoglobulins reflects a quantitative increase in specificities detectable at lower concentrations in young mice. Scand J Immunol 1996;44:437-443.

  28. Lacroix-Desmazes S, Mouthon L, Kaveri SV, Kazatchkine MD, Weksler ME. Stability of natural self-reactive antibody repertories during aging. J Clin Immunol 1999;19:26-34.

  29. Ligthart GJ, Radl J, Corberand JX, van Nieuwkoop JA, van Staalduinen GJ, van Helmond DJ, et al. Monoclonal gammopathies in human aging: increased occurrence with age and correlation with health status. Mech Ageing Dev 1990;52:235-243.

  30. Merlini G, Farhangi M, Osserman EF. Monoclonal immunoglobulins with antibody activity in myeloma,macroglobulinemia and related plasma cell dyscrasias. Semin Oncol 1986;13:350-365.

  31. Okada T, Abe M, Takiura F, Hirose S, Shirai T. Distinct surface phenotypes of b cells responsible for spontaneous production of IgM and IgG anti-DNA antibodies in autoimmune-prone NZB x NZW F1 mice. Autoimmunity 1990;7:109-120.

  32. Zheng B, Han S, Takahashi Y, Kelsoe G. Immunosenescence and germinal center reaction. Immunol Rev 1997;160:63-77.

  33. Solana R, Mariani E. NK and NK/T cells in human senescence. Vaccine 2000;18:1613-1620.

  34. Smith MJ, Street SE, Trapani JA. Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. J Immunol 2003;171:515-518.

  35. Lanier LL. NK cell receptors. Annu Rev Immunol 1998;16:359-393.

  36. Pawelec G, Solana R, Remarque E, Mariani E. Impact of aging on innate immunity. J Leukoc Biol 1998;64:703-712.

  37. Borrego F, Alonso MC, Galiani MD, Carracedo J, Ramirez R, Ostos B, et al. NK phenotypic markers and IL2 response in NK cells from elderly people. Exp Gerontol 1999;34:253-265.

  38. Tarazona R, de la Rosa O, Alonso C, Ostos B, Espejo J, Pena J, et al. Increased expression on NK cell markers on T lymphocytes in aging and chronic activation on the immune system reflects the accumulation of effector/senescent T cells. Mech Ageing Dev 2000; 121:77-88.

  39. Sze DM, Giesaitis G, Brown RD, Raitakari M, Gibson J, Ho J, et al. Clonal cytotoxic T cells are expanded in myeloma and resides in the CD8(+)CD57(+)CD28(-) compartment. Blood 2001;98:2817-2827.

  40. Carmichael A, Jin X, Sissons P, Borysiewicz L. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response to HIV-1 and Epstein-Barr virus in late disease. J Exp Med 1993;177:249-256.

  41. Kutza J, Murasko DM. Effects of aging on natural killer cell activity and activation by interleukin-2 and IFN-alpha. Cell Immunol 1994;155:195-204.

  42. Kutza J, Murasko DM. Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples. Mech Ageing Dev 1996;90:209-222.

  43. Krishnaraj R, Bhooma T. Cytokine sensitivity of human NK cells during immunosenescence, 2 IL2 induced interferon gamma secretion. Immunol Lett 1996;50:59-63.

  44. Krishnaraj R. Senescence and cytokines modulate the NK cell expression. Mech Ageing Dev 1997;96:89-101.

  45. McNerlan SE, Rea IM, Alexander HD, Morris TC. Changes in natural killer cells, the CD57CD8 subset, and related cytokines in healthy aging. J Clin Immunol 1998;18:31-38.

  46. Okada T, Liai T, Kawachi Y, Moroda T, Takii Y, Hatakeyama K, et al. Origin of CD57+ T cells vich increase at tumour sites in patients with colorectal cancer. Clin Exp Immunol 1995;102:159-166.

  47. Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, Motoki K, et al. CD1d-restricted and TCR-mediated activation of valpha 14 NKT cells by glycosylceramides. Science 1997;278:1626-1629.

  48. Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, Sato H, et al. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated valpha14 NKT cells. Proc Natl Acad Sci USA 1998;95:5690-5693.

  49. Nicol A, Nieda M, Koezuka Y, Pocelli S, Suzuki K, Tadokoro K, et al. Human invariant valpha24+ natural killer T cells activated by alpha galactosylceramide (KRN7000) have cytotoxic anti-tumour activity through mechanisms distinct from T cells and natural killer cells. Immunology 2000;99:229-234.

  50. Robinson KA, Baughman W, Rothrock G, Barret NL, Pass M, Lexau C, et al. Epidemiology of invasive Streptococcus pneumoniae infections in the United States, 1995-1998: Opportunities for prevention in the conjugate vaccine era. JAMA 2001;285:1729-1735.

  51. Neuzil KM. Influenza: New insights into an old disease. Curr Infect Dis Rep 2000;2:224-230.

  52. Mohan VP, Scanga CA, Yu K, Scott HM, Tanaka KE, Tsang E, et al. Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology. Infect Immun 2001;69:1847-1855.

  53. Fagnoni FF, Vescovini R, Passeri G, Bolonga G, Pedrazzoni M, Lavagetto G, et al. Shortage of circulating naïve CD8(+) T cells provides new insights on immunodeficiency in aging. Blood 2000;95:2860-2868.

  54. Ginaldi L, Loreto MF, Corsi MP, Modesti M, de Martinis M. Immunosenescence and infectious diseases. Microbes Infect 2001;3:851-857.

  55. Ershler WB, Longo DL. Aging and cancer: issues of basic and clinical science. J Natl Cancer Inst 1997;89: 1489-1497.

  56. Yancik R. Cancer burden in the aged: an epidemiologic and demographic overview. Cancer 1997;80:1273-1280.

  57. Burns EA, Leventhal EA. Aging, immunity and cancer. Cancer Control 2000;7:513-522.

  58. Imai K, Matsuyama S, Miyake S, Suga K, Nakachi K. Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an ll-year follow-up study of a general population. Lancet 2000;356:1795-1799.

  59. Takeuchi H, Maehara Y, Tokunaga E, Koga T, Kakeji Y, Sugimachi K. Prognostic significance of natural killer cell activity in patients with gastric carcinoma: a multivariate analysis. Am J Gastroenterol 2001;96:574-578.

  60. Mackay IR, Gershwin ME. The nature of autoimmune disease. Semin Liver Dis 1997;17:3-11.




2020     |     www.medigraphic.com