2004, Número 4
<< Anterior Siguiente >>
Rev Inst Nal Enf Resp Mex 2004; 17 (4)
Aspectos inmunológicos del envejecimiento.
Sada-Ovalle I, Gorocica RP, Lascurain LR, Zenteno GE
Idioma: Español
Referencias bibliográficas: 60
Paginas: 293-300
Archivo PDF: 80.62 Kb.
RESUMEN
La inmunosenescencia es un proceso complejo que involucra múltiples cambios en las poblaciones linfocitarias. Estos cambios en el adulto mayor incrementan la incidencia y severidad de las enfermedades infecciosas y algunos cánceres. En este artículo revisamos algunos de los cambios inmunológicos más relevantes que han sido descritos durante el envejecimiento y su asociación con algunas patologías.
REFERENCIAS (EN ESTE ARTÍCULO)
INEGI. Censo de Población y Vivienda del año 2000. (http://www.inegi.gob.mx/est/default.asp?c=2344).
Harrison DE. Normal function of transplanted mouse erythrocyte precursors for 21 months beyond donor life spans. Nat New Biol 1972;237:220-222.
Lansdrop PM, Dragowska W, Thomas TE, Little MT, Madani H. Age-related decline in proliferative potential of purified stem cell candidates. Blood Cells 1994;20:376-380.
Geiger H, Van Zant G. The aging of lympho-hematopoietic stem cells. Nat Immunol 2002;3:329-333.
Nilsson-Ehle H, Swolin B, Westin J. Bone marrow progenitor cell growth and karyotype changes in healthy 88-year-old subjects. Eur J Haematol 1995;55:14-18.
Yu S, Abel L, Globerson A. Thymocyte progenitors and T cell development in aging. Mech Ageing Dev 1997;94:103-111.
Stephan RP, Reilly CR, Witte PL. Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age. Blood 1998;91:75-88.
Markert ML, Boeck A, Hale LP, Kloster AL, McLaughlin TM, Batchvarova MN, et al. Transplantation of thymus tissue in complete DiGeorge Syndrome. N Engl J Med 1999;341:1180-1189.
Phyllis JL, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol 2004;5:133-139.
Ceredig R, Rolink TA. A positive look at double-negative thymocytes. Nat Rev Immunol 2002;2:2-10.
Haynes BF, Market ML, Sempowski GD, Patel DD, Hale LP. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol 2000;18:529-560.
Fagnoni FF, Vescovini R, Passeri G, Bolonga G, Pedrazzoni M, Lavagetto G, et al. Shortage of circulating naive CD8 (+) T cells provides new insights on immunodeficiency in aging. Blood 2000;95:2860-2868.
De Rosa SC, Herzenberg LA, Roederer M. 11-color,13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T cell receptor diversity. Nat Med 2001;7:245-248.
Kong FK, Chen CL, Six A, Hockett RD, Cooper MD. T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool. Proc Natl Acad Sci USA 1999;96:1536-1540.
Poulin JF, Viswanathan MN, Harris JM, Komanduri KV, Wieder E, Ringuette N. Direct evidence for thymic function in adult humans. J Exp Med 1999;190: 479-486.
Stuling T, Maczek C, Bock G, Majdic O, Wick G. Reference intervals for human peripheral boold lymphocyte subpopulations from healthy young and aged subjects. Int Arch Allergy Immunol 1995;108:205-210.
Grossman A, Maggio-Price L, Jinneman JC, Rabinovitch PS. Influence of aging on intracellular free calcium and proliferation of mouse T-cell subsets from various lymphoid organs. Cell Immunol 1991;135:118-131.
Posnett DN, Sinha R, Kabak S, Russo C. Clonal population of T cells in normal elderly humans: the T cell equivalent to “benign monoclonal gammapathy”. J Exp Med 1994;179:609-618.
Boucher N, Defeu-Duchesne T, Vicaut E, Farge D, Effros RB, Schachter F. CD28 expression in T cell aging and human longevity. Exp Gerontol 1998;33:267-282.
Batliwalla FM, Rufer N, Lansdrop PM, Gregersen PK. Oligoclonal expansions in the CD8(+)CD28(-) T cells largely explain the shorter telomers detected in this subset: analysis by flow FISH. Hum Immunol 2000;61:951-958.
LeMaoult J, Szabo P, Weksler ME. Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol Rev 1997;160:115-126.
Thomsen O, Kettel K. Die sturke der menschlichen isoagglutninne und entsperchenden. Blutkorperperchenrezeptoren im vershiedenenen. Lebensatern 2 Immunitatsforsch 1929;63:67-93.
Baumgartner L. Age and antibody production: Qualitative changes in antisera associated with aging. J Immunol 1934;27:407-416.
Schwab R, Walters CA, Weksler ME. Host defense mechanisms and aging. Semin Oncol 1989;16:20-27.
Weksler ME. Changes in the B-cell repertoire with age. Vaccine 2000;18:1624-1628.
Hallgren HM, Buckley CE, Gilbertsen VA, Yunis EJ. Lymphocyte Phytohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans. J Immunol 1973;111:1101-1107.
Nobrega A, Haury M, Gueret R, Coutinho A, Weksler ME. The age-associated increased in autoreactive immunoglobulins reflects a quantitative increase in specificities detectable at lower concentrations in young mice. Scand J Immunol 1996;44:437-443.
Lacroix-Desmazes S, Mouthon L, Kaveri SV, Kazatchkine MD, Weksler ME. Stability of natural self-reactive antibody repertories during aging. J Clin Immunol 1999;19:26-34.
Ligthart GJ, Radl J, Corberand JX, van Nieuwkoop JA, van Staalduinen GJ, van Helmond DJ, et al. Monoclonal gammopathies in human aging: increased occurrence with age and correlation with health status. Mech Ageing Dev 1990;52:235-243.
Merlini G, Farhangi M, Osserman EF. Monoclonal immunoglobulins with antibody activity in myeloma,macroglobulinemia and related plasma cell dyscrasias. Semin Oncol 1986;13:350-365.
Okada T, Abe M, Takiura F, Hirose S, Shirai T. Distinct surface phenotypes of b cells responsible for spontaneous production of IgM and IgG anti-DNA antibodies in autoimmune-prone NZB x NZW F1 mice. Autoimmunity 1990;7:109-120.
Zheng B, Han S, Takahashi Y, Kelsoe G. Immunosenescence and germinal center reaction. Immunol Rev 1997;160:63-77.
Solana R, Mariani E. NK and NK/T cells in human senescence. Vaccine 2000;18:1613-1620.
Smith MJ, Street SE, Trapani JA. Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. J Immunol 2003;171:515-518.
Lanier LL. NK cell receptors. Annu Rev Immunol 1998;16:359-393.
Pawelec G, Solana R, Remarque E, Mariani E. Impact of aging on innate immunity. J Leukoc Biol 1998;64:703-712.
Borrego F, Alonso MC, Galiani MD, Carracedo J, Ramirez R, Ostos B, et al. NK phenotypic markers and IL2 response in NK cells from elderly people. Exp Gerontol 1999;34:253-265.
Tarazona R, de la Rosa O, Alonso C, Ostos B, Espejo J, Pena J, et al. Increased expression on NK cell markers on T lymphocytes in aging and chronic activation on the immune system reflects the accumulation of effector/senescent T cells. Mech Ageing Dev 2000; 121:77-88.
Sze DM, Giesaitis G, Brown RD, Raitakari M, Gibson J, Ho J, et al. Clonal cytotoxic T cells are expanded in myeloma and resides in the CD8(+)CD57(+)CD28(-) compartment. Blood 2001;98:2817-2827.
Carmichael A, Jin X, Sissons P, Borysiewicz L. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response to HIV-1 and Epstein-Barr virus in late disease. J Exp Med 1993;177:249-256.
Kutza J, Murasko DM. Effects of aging on natural killer cell activity and activation by interleukin-2 and IFN-alpha. Cell Immunol 1994;155:195-204.
Kutza J, Murasko DM. Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples. Mech Ageing Dev 1996;90:209-222.
Krishnaraj R, Bhooma T. Cytokine sensitivity of human NK cells during immunosenescence, 2 IL2 induced interferon gamma secretion. Immunol Lett 1996;50:59-63.
Krishnaraj R. Senescence and cytokines modulate the NK cell expression. Mech Ageing Dev 1997;96:89-101.
McNerlan SE, Rea IM, Alexander HD, Morris TC. Changes in natural killer cells, the CD57CD8 subset, and related cytokines in healthy aging. J Clin Immunol 1998;18:31-38.
Okada T, Liai T, Kawachi Y, Moroda T, Takii Y, Hatakeyama K, et al. Origin of CD57+ T cells vich increase at tumour sites in patients with colorectal cancer. Clin Exp Immunol 1995;102:159-166.
Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, Motoki K, et al. CD1d-restricted and TCR-mediated activation of valpha 14 NKT cells by glycosylceramides. Science 1997;278:1626-1629.
Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, Sato H, et al. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated valpha14 NKT cells. Proc Natl Acad Sci USA 1998;95:5690-5693.
Nicol A, Nieda M, Koezuka Y, Pocelli S, Suzuki K, Tadokoro K, et al. Human invariant valpha24+ natural killer T cells activated by alpha galactosylceramide (KRN7000) have cytotoxic anti-tumour activity through mechanisms distinct from T cells and natural killer cells. Immunology 2000;99:229-234.
Robinson KA, Baughman W, Rothrock G, Barret NL, Pass M, Lexau C, et al. Epidemiology of invasive Streptococcus pneumoniae infections in the United States, 1995-1998: Opportunities for prevention in the conjugate vaccine era. JAMA 2001;285:1729-1735.
Neuzil KM. Influenza: New insights into an old disease. Curr Infect Dis Rep 2000;2:224-230.
Mohan VP, Scanga CA, Yu K, Scott HM, Tanaka KE, Tsang E, et al. Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology. Infect Immun 2001;69:1847-1855.
Fagnoni FF, Vescovini R, Passeri G, Bolonga G, Pedrazzoni M, Lavagetto G, et al. Shortage of circulating naïve CD8(+) T cells provides new insights on immunodeficiency in aging. Blood 2000;95:2860-2868.
Ginaldi L, Loreto MF, Corsi MP, Modesti M, de Martinis M. Immunosenescence and infectious diseases. Microbes Infect 2001;3:851-857.
Ershler WB, Longo DL. Aging and cancer: issues of basic and clinical science. J Natl Cancer Inst 1997;89: 1489-1497.
Yancik R. Cancer burden in the aged: an epidemiologic and demographic overview. Cancer 1997;80:1273-1280.
Burns EA, Leventhal EA. Aging, immunity and cancer. Cancer Control 2000;7:513-522.
Imai K, Matsuyama S, Miyake S, Suga K, Nakachi K. Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an ll-year follow-up study of a general population. Lancet 2000;356:1795-1799.
Takeuchi H, Maehara Y, Tokunaga E, Koga T, Kakeji Y, Sugimachi K. Prognostic significance of natural killer cell activity in patients with gastric carcinoma: a multivariate analysis. Am J Gastroenterol 2001;96:574-578.
Mackay IR, Gershwin ME. The nature of autoimmune disease. Semin Liver Dis 1997;17:3-11.