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ISSN 0188-9796 (Print)

2007, Number 4

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Rev Endocrinol Nutr 2007; 15 (4)

The value of use of growth hormone in elderly

Zúñiga-González S

Language: Spanish
References: 28
Page: 217-221
PDF size: 106.94 Kb.


ABSTRACT

The adult-onset growth hormone deficiency (AO-GHD), is a diagnosis rarely found. This growth hormone (GH) deficiency, affect the patient life-quality, causing metabolic changes, adverse profile of cardiovascular risk, lower bone mineral density, changes in muscular strength, and others. The main causes of AO-GHD: hypotalamic-pituitary diseases, cranial trauma or irradiation, subarachnoid haemorrhage, infiltrative diseases, genetics disturbance. Among the benefits of GH therapy in hypopituitary patients we can find: central adiposity diminishing, improve of lipid profile, reduced cytoquines, endothelial function and ventricular mass score improvement. The recombinant growth hormone (GHr) treatment in adult patient, can increase glucose into normal ranges. This doesn’t cause growth in de novo neoplasms, or re-growth speed increase in previous pituitary tumours. Secondary effects are dosis-dependent and more frequently in high doses. Normal aging is associated with a decline in GH secretion. The actual way of GHr substitution try to improve the quality of life in the elderly patient, giving benefits like mentioned. The use of low GHr doses even in alternative days, improve the patient perception of well-being, improvement of waist circumference and lipid profile.


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