Ruiz DGJ, Tarin ALC

Language: Spanish
References: 22
Page: 32-35
PDF size: 169.57 Kb.

ABSTRACT

In B-cell chronic lymphocytic leukemia (B-CL ), different prognostic factors have been proposed to predict the clinical course of the disease. Recently, there has been added a new prognostic factor defined by the expression of 70kDa protein that is associated with T-cell receptor zeta chain and known as ZAP -70. This protein is not expressed in normal B lymphocytes but is expressed in those of a B-CL subgroup which do not display IgVH heavy chain variable-region gene mutations. Recent studies indicate that the expression of this protein in leukemic lymphocytes is associated to a more aggressive course of the disease. Likewise, it has been pointed out that the determination of ZAP -70 can provide a simpler prognostic factor than the present characterization of the IgVH gene mutational state. Studies looking for this protein in Mexico have started, despite the fact that chronic lymphocytic leukemia in extremely infrequent in our country.

REFERENCES

1. Hernández-Ramírez P. Leucemia linfoide crónica. Diagnóstico y factores pronósticos. Rev Cubana Hematol Inmunol Hemoter 2003;19:2-3.

2. Naylor M, Capra JD. Mutational status of IgVH genes provides clinically valuable information in B-cell chronic lymphocytic leukemia. Blood 1999;94:1837-9.

3. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated IgVH genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999;94:1848-54.

4. Matrai Z, Lin K, Dennis M, et al. CD38 expression and IgVH gene mutation in B-cell chronic lymphocytic leukemia. Blood 2001;97:1902.

5. Damle RN , Wasil T, Fais F, et al. IgV gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999;94:1840-7.

6. Stilgenbauer S, Bullinger L, Lichter P, Dohner H. Genetics of chronic lymphocytic leukemia: genomic aberrations and V (H) gene mutation status in pathogenesis and clinical course. Leukemia 2002;16:993-1007.

7. Fais F, Ghiotto F, Hashimoto S, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998;102:1515-25.

8. Rai KR, Dohner H, Keating MJ, Montserrat E. Chronic lymphocytic leukemia: case-based session. Hematology 2001:140-56.

9. Kay NE , Hamblin TJ, Jelinek DF, et al. Chronic lymphocytic leukemia. Hematology 2002:193-213.

10. M ainou-Fowler I, Dignum HM, Proctor SJ, Summerfield GP. The prognostic value of CD38 expression and its quantification in B cell chronic lymphocytic leukemia (B-CL ). Leuk Lymphoma 2004;45:455-62.

11. Bolen JB. Nonreceptor tyrosine protein kinases. Oncogene 1993;8:2025-31.

12. Chan AC , Iwashima M, Turck CW, Weiss A. ZAP -70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 1992;71:649-62.

13. Chan AC , Irving BA, Fraser JD, Weiss A. The x chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP -70, a 70 kDa tyrosine phosphoprotein. Proc Natl Acad Sci USA 1991;88:9166-70.

14. Chen L, Widhopf G, Huynh L, et al. Expression of ZAP -70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2002;100:4609-14.

15. Kane LP , Lin J, Weiss A. Signal transduction by the TCR for antigen. Curr Opin Immunol 2000;12:242-9.

16. Rosenwald A, Alizadeh AA , Widhopf G, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001;194:1639-47.

17. Crespo M, Bosh F, Villamor N, et al. ZAP -70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003;348:1764-75.

18. Wiestner A, Rosenwald A, Barry TS , et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood 2003;101:4944-51.

19. Orchard JA, Ibbotson RE , Davis Z, et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. Lancet 2004;363:105-11.

20. Admirand JH, Rassidakis GZ, Abruzzo LV, et al. Immunohistochemical detection of ZAP -70 in 341 cases of non-Hodgkin and Hodgkin lymphomas. Med Pathol 2004;17:954-61.

21. Ruiz-Argüelles GJ, Velázquez BM, Apreza-Molina MG, et al. Chronic lymphocytic leukemia is infrequent in Mexican mestizos. Int J Hematol 1999;69:253-5.

22. Alemán-Hoey DD, Ruiz-Argüelles GJ, Verduzco-Rodriguez L, López-Ariza B, Labardini JR. Leucemia linfocítica crónica. I. Experiencia de 35 años en el Instituto Nacional de la Nutrición Salvador Zubirán. Rev Invest Clin (Méx) 1982;34:151-6.