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Colegio de Medicina Interna de México.

2006, Number 3

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Med Int Mex 2006; 22 (3)

Preeclampsia and endothelial dysfunction. Physiopathologic bases

Duarte MJ, Díaz MS, Rubio GJ, Lee Eng CVE, Fernández PLY, Castro BJ, Ramos REM

Language: Spanish
References: 80
Page: 220-230
PDF size: 288.31 Kb.


ABSTRACT

Preeclampsia affects 5-7% of all pregnancies. A placental defect might cause the disease. Our understanding of normal placental vasculogenesis and of the pathophysiology of preeclampsia has advanced significantly. Several early observations support the hypothesis for a placental trigger for preeclampsia. Many alterations are implicated in the genesis of preeclampsia. These are altered oxidative stress, increased lipid peroxidation, abnormal reactivity to the vasopressors such as angiotensin II, and abnormal endothelium dependent vasorelaxation, represent some alterations found in preeclampsia. We review recent advances of the pathogenesis of preeclampsia. Evidence exist that preeclampsia may involve an imbalance among the proangiogenic and antiangiogenic factors that regulate placental and systemic endothelial health.


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