2006, Number 2
Blood and marrow stem cells transplantation in multiple sclerosis. Present and future in its use and selection of patients
Skromne EE, Rivera OVM, Ordoñez BL, Ontaneda JD
Language: Spanish
References: 9
Page: 164-169
PDF size: 70.20 Kb.
ABSTRACT
Multiple sclerosis (MS) is a disease with an autoinmune pathophysiology. A new and promising treatment in this group of patients is the blood and marrow stem cells transplantation which is currently an experimental treatment with evident immuno-suppressant effects. It has not been demonstrated any effect on neurodegeneration and it is preferred to use this procedure as a non-conventional treatment of multiple sclerosis. Selection of patients should be strict, mainly in patients with moderate severity and an important inflammatory component. It is not a rescue treatment because its utility in progressive forms or advanced MS has not been demonstrated and the risk is high. This review includes an analysis of the current protocols and their results.REFERENCES
Comi L, Kappos M, Clanet G, Ebers A, Fassas, et al. Guidelines for autologous blood and marrow stem cell transplantation in multiple sclerosis: a consensus report written on behalf of the European Group for Blood and Marrow Transplantation and the European Charcot Foundation. J Neurology 2000; 247: 376-82.