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Academia Mexicana de Neurología, A.C.

2006, Number 1

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Rev Mex Neuroci 2006; 7 (1)

Preliminary study of the prevalence of antigliadine antibodies in Cuban patients with spinocerebellar ataxia type 2

Almaguer MLE, Rodríguez AY, Martínes GE, Almaguer GD, González ZY, Sánchez CG, Coello AD

Language: Spanish
References: 16
Page: 76-79
PDF size: 67.00 Kb.


ABSTRACT

Introduction: Neurology of gluten sensitivity is increasingly complex. In particular, it has been suggested that gluten ataxia is a different disease entity, which represents the more frequent cause of idiopathic ataxias. Nevertheless, recently it has been found an elevated prevalence of gluten sensitivity in hereditary ataxia patients. Objective: To test if spinocerebellar ataxia type 2 is associated to gluten sensitivity. Subjects and Method: We determined the antigliadin antibodies (AGA) prevalence in 30 SCA2 patients and in 30 matched controls. The obtained prevalence results were compared using the chi-square. In order to compare the severity of the disease in AGA positive and AGA negative patients we used the Mann-Whitney U test. Results: 23.3% of patients were AGA positive, whereas this was observed only in the 6.67% of the controls; significant differences between the groups were obtained (χ2 = 13.39; p ‹ 0.001). However, we failed to obtain significant differences in disease severity between AGA positive and AGA negative patients. Conclusion: These results suggest that antigliadin antibodies could be an epiphenomenon in SCA2, whose contribution to the clinical syndrome needs to be clarified.


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