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Academia Mexicana de Neurología, A.C.

2006, Number 1

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Rev Mex Neuroci 2006; 7 (1)

Genic apoptosis regulation via p38 in neurotoxicity processes

Segura TJE, Flores SME, Román RF

Language: Spanish
References: 54
Page: 55-68
PDF size: 230.61 Kb.


ABSTRACT

A lot of studies have show that GMS induces two kinds of cellular death: a fast death of necrotic kind which produces the liberation of excitatory neurotransmitters like Glutamate and GABA (at postnatal age), this provokes a second kind of cellular death by apoptosis (slow dead), that eventually produces the activation of the MAPKs pathway, which are: ERK, JNK and p38. These promote the activation of early gen that under conditions of stress produce alterations in the profiles of transcription factors; therefore, alterations in the genic expression. Nevertheless, it is important to know the participation of the p38 pathway, in neurototoxicity; which could be associated with possible changes in the levels of expression of early genes correlationated with the apoptotic process of neuronal death; throughout the identification of these responsible genes (participant) in the process of neuronal death; they could contribute to the design of new therapeutic strategies to prevent the neuroexcitotoxicity common phenomenon in different chronical neurodegenerative diseases.


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