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Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara y del OPD Hospitales Civiles de Guadalajara

2006, Number 3

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Inv Salud 2006; 8 (3)

Neuroendocrine regulation of hunger, satiety and maintenance of energy balance

González HME, Ambrosio MKG, Sánchez ES

Language: Spanish
References: 67
Page: 191-200
PDF size: 397.62 Kb.


ABSTRACT

Hunger, satiety and energy balance are regulated by a redundant neuroendocrine system located in the hypothalamus. The system includes central and peripheral signals and several messenger molecules with orexigenic and anorexigenic effects as well as sensory afferent inputs, behavioral and mechanical stimuli.
Coordinated function of all components of this appetite-regulatory system maintains the daily pattern of food intake and minimizes changes in fatmass and body weight.
Gastrointestinal hormones acting as short time signals regulate the size of food intake at each meal. Long time signals, reflecting body fat content, provide a feedback signal to the central nervous system.
Knowledge of the site and mode of action of signal-producing networks, hypothalamic pathways involved and the mechanisms participating in the control of energy homeostasis and eating behavior will provide new insights for designing better therapeutic strategies to treat appetite disturbances related to anorexia or obesity.


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