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Instituto Nacional de Neurología y Neurocirugía

2006, Number 1

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Arch Neurocien 2006; 11 (1)

Memory dysfunction in huntington’s disease

Montoya A, Achim AM, Menear M, Chouinard S, Richer F, Lepage M, Ruiz-López I

Language: Spanish
References: 47
Page: 11-17
PDF size: 95.37 Kb.


ABSTRACT

Objective: some previous studies indicate that HD patients’ performance on tests of recognition memory is normal or less impaired than their performance on tests of free recall, and have interpreted this patternas evidence for retrieval-based episodic memory impairment. The present study assessed associative recognition memory in a group of patients suffering Huntington’s disease and a control group. Methods: A neurocognitive battery was administered to 15 participants with Huntington’s disease, and a group of 20 normal controls matched to the patients on age, gender and level of education. Episodic memory was assessed using a recognition memory task during which subjects made item recognition judgments (old/new decisions) and associative recognition judgments (intact/rearranged decisions). Results: HD patients performed more poorly on episodic measures than controls did. HD patients showed greater impairment on tests of associative recognition memory compared to healthy normal subjects. In addition, HD patients show greater impairment on tests of associative recognition memory relative to tests of item recognition memory. Conclusions: These results suggest that HD patients suffer from a recognition memory deficit thatis similar in magnitude to the recognized deficit in recall memory. Thus, the notion of memory impairment caused solely by a generalized deficit in retrieval processes is not supported.


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