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Instituto Nacional de Neurología y Neurocirugía

2006, Número 1

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Arch Neurocien 2006; 11 (1)


Disfunción de la memoria episódica en la enfermedad de Huntington

Montoya A, Achim AM, Menear M, Chouinard S, Richer F, Lepage M, Ruiz-López I

Idioma: Español
Referencias bibliográficas: 47
Paginas: 11-17
Archivo PDF: 95.37 Kb.


RESUMEN

Objetivo: estudios previos han mostrado que el rendimiento de los pacientes con enfermedad de Huntington (EH) en pruebas del recuerdo es normal o afectado de manera mínima en comparación al rendimiento en pruebas de reconocimiento. Este patrón neuropsicológico ha sido interpretado como el resultado de un proceso de recuperación ineficaz. En este estudio pretendemos evaluar la memoria episódica en pacientes afectados por la EH y en sujetos control. Métodos: se administró una batería neurocognitiva a un grupo de 15 pacientes con la EH y un grupo de 20 sujetos sanos comparables en sexo,edad y nivel escolar. La memoria episódica se evaluó mediante una prueba de reconocimiento consistente en varias preguntas (nuevos/previamente estudiados) y una prueba de reconocimiento de asociaciones (pares intactos/pares reacomodados). Resultados: los pacientes con la EH mostraron un menor rendimiento en las evaluaciones de la memoria episódica en relación a los sujetos control. A su vez, los pacientes con EH presentaron una afectación mayor en el reconocimiento de asociaciones comparado con el rendimiento observado en el grupo control. Adicionalmente, se encontró que los pacientes tuvieron una mayor dificultad para el reconocimiento de asociaciones que para el de reconocimiento de preguntas. Conclusiones: los resultados indican que en los pacientes con EH el reconocimiento se encuentra afectado de manera muy similar al recuerdo, consecuentemente la afectación de la memoria episódica en estos pacientes no puede explicarse sólo como el resultado de un déficit generalizado en los procesos de recuperación.


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