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ISSN 0016-3813 (Print)

2006, Number 3

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Gac Med Mex 2006; 142 (3)

influence of alleles and haplotypes of the main histocompatibility complex on the susceptibility to systemic lupus erythematosus in the Mexican population.

Granados J, Zúñiga J, Acuña-Alonzo V, Rosettid F, Vargas-Alarcóne G

Language: Spanish
References: 22
Page: 195-199
PDF size: 435.75 Kb.


ABSTRACT

HLA alelles with susceptibility to systemic lupus erythematosus (SLE) have been found in many ethnic groups. In addition, some neighboring genes such as TNF-α and HSP70, that may contribute to this disease have also been described. Interestingly some of the genetic associations differ among several ethnic groups, which might suggest that ethnicity plays an important role in the predisposition to SLE. In this study, we analyze gene frequencies of HLA-DRB1, DQA1, DQB1, HSP70-2 alelles and the polymorphism of TNF-α promoter region among 81 mexican mestizo SLE patients. A control group of 99 healthy mexican mestizos was included. We found that the HLA-DRB1*0301-DQA1*0501-DQB1*0201 haplotype was significantly increased in SLE patients compared to healthy controls (p=0.01, OR=2.97, IC 95%=1.18-7.68). The DRB1*1501 allele was more frequent among patients than among controls. A significantly decreased frequency of the HLA-DRB1*0802 alelle in SLE patients was also observed. Since the HLA alelles associated with SLE are uncommon in mexican ethnic groups, we performed admixture estimates analysis and found that the incorporation of SLE susceptibility markers in mexican mestizo groups might have come from genetic admixture with Caucasian populations.


REFERENCES

  1. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-1277.

  2. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.

  3. Schur PH. Genetics of systemic lupus erythematosus. Lupus. 1995;4:425-437.

  4. Harley JB, Moser KL, Gaffney PM, Behrens TW. The genetics of human systemic lupus erythematosus. Curr Opin Immunol 1998;10:690-696.

  5. Hartung K, Baur MP, Coldewey R, Fricke M, Kalden JR, Lakomek HJ, et al. Major histocompatibility complex haplotypes and complement C4 alleles in systemic lupus erythematosus. Results of a multicenter study. J Clin Invest 1992;90:1346-1351.

  6. Yao Z, Kimura A, Hartung K, Haas PJ, Volgger A, Brunnler G, et al. Polymorphism of the DQA1 promoter region (QAP) and DRB1, QAP, DQA1, DQB1 haplotypes in systemic lupus erythematosus. SLE Study Group members. Immunogenetics 1993;38:421-429.

  7. Burgos-Vargas R, Granados J. Ankylosing spondylitis and related disease in the Mexican mestizo. Spine 1990;4:161-167.

  8. Rood MJ, van Krugten MV, Zanelli E, van der Linden MW, Keijsers V, Schreuder GM, et al. TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus. Arthritis Rheum 2000;43129-134.

  9. Howard PF, Hochberg MC, Bias WB, Arnett FC Jr, McLean RH. Relationship between C4 null genes, HLA-D region antigens, and genetic susceptibility to systemic lupus erythematosus in Caucasian and black Americans Am J Med 1986;81:187-193.

  10. Fielder AH, Walport MJ, Batchelor JR, Rynes RI, Black CM, Dodi IA, et al. Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility. Br Med J 1983;286:425-428.

  11. Dunckley H, Gatenby PA, Hawkins B, Naito S, Serjeantson SW. Deficiency of C4A is a genetic determinant of systemic lupus erythematosus in three ethnic groups. J Immunogenet 1987;14:209-218.

  12. Granados J, Vargas-Alarcon G, Andrade F, Melin-Aldana H, Alcocer-Varela J, Alarcon-Segovia D. The role of HLA-DR alleles and complotypes through the ethnic barrier in systemic lupus erythematosus in Mexicans. Lupus 1996;5:184-189.

  13. Rudwaleit M, Tikly M, Khamashta M, Gibson K, Klinke J, Hughes G, et al. Interethnic differences in the association of tumor necrosis factor promoter polymorphisms with systemic lupus erythematosus. J Rheumatol. 1996;23:1725-1728.

  14. Jarjour W, Reed AM, Gauthier J, Hunt S 3rd, Winfield JB. The 8.5-kb PstI allele of the stress protein gene, Hsp70-2: an independent risk factor for systemic lupus erythematosus in African Americans? Hum Immunol 1996; 45:59-63.

  15. Theofilopoulos AN. The basis of autoimmunity. Genetic predisposition. Immunol Today 1995;16:150-159.

  16. Brennan P, Hajeer A, Ong KR, Worthington J, John S, Thomson W, et al. Allelic markers close to prolactin are associated with HLA-DRB1 susceptibility alleles among women with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum 1997;40:1383-1386.

  17. Lisker R, Perez-Briceno R, Granados J, Babinsky V. Gene frequencies and admixture estimates in the state of Puebla, Mexico. Am J Phys Anthropol 1988;76:331-335.

  18. Davis RW, Thomas M, Cameron J, St John TP, Scherer S, Padgett RA. Rapid DNA isolations for enzymatic and hybridization analysis. Methods Enzymol. 1980;65:404-411.

  19. http://www.ncbi.nlm.nih.gov/mhc

  20. Wang J. Maximum likelihood estimation of admixture proportions from genetic data. Genetics 2003;64:747-765.

  21. Molokhia M, Hoggart C, Patrick AL, McKeigue P. Risk for rheumatic disease in relation to ethnicity and admixture. Arthritis Res 2002;(2):115–125.

  22. Alarcón-Segovia D, Alarcón-Riquelme ME, Cardiel MH, Caeiro F, Massardo L, Villa AR, et al. Grupo Latinoamericano de Estudio del Lupus Eritematoso (GLADEL). Familial aggregation of systemic lupus erythematosus, rehumatoid arthritis, and other autoimmune diseases in 1177 lupus patients from the GLADEL cohort. Arthritis Rheum 2005;52:1138.1147.




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