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2006, Number 1

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Gac Med Mex 2006; 142 (1)

Adenomatoid tumor of the genital tract. Clinical, pathological and inmunohistochemical study in 9 cases.

Canedo-Patzi AM, León-Bojorgea B, Ortíz-Hidalgo C

Language: Spanish
References: 36
Page: 59-66
PDF size: 643.73 Kb.


ABSTRACT

Objetive: Describe the histological and immunohistochemical features of nine genital tract adenomatoid tumors .
Material and methods: Nine cases of adenomatoid tumors were collected from the files of the Pathology department at a private hospital (ABC Hospital). Tumors were studied from a histological and inmunohistochemical perspective.
Results: Eight women and one man were studied. Age range was 28- 54 yrs. Tumors were located in the uterus (seven), fallopian tube (one) and epididymis (one). Tumor size ranged from 0.4 to 5.8 cm. We observed three histological patterns: adenoid, angiomatoid and solid. Arrangement of the neoplastic tubules around fascicles of smooth muscle; angiomatoid pattern with a peripheral location, and solid and adenoid patterns with a central location in the tumor were some of the observed histological features. Immunohistochemically all tumors exhibited strong and diffuse positivity for calretinin and AE1/AE3. Thrombomodulin was positive in all tumors (focal and weak in angiomatoid pattern and diffuse and strong in adenoid and solid patterns). The CK5/6 antibody was positive in seven tumors (diffuse in three and focal in four). Two tumors were negative for this marker. All tumors were negative for CD31.
Conclusions: The immunophenotype of the adenomatoid tumors in our series confirms their mesothelial origin.


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