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2006, Número 1

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Gac Med Mex 2006; 142 (1)


La ghrelina y su importancia con el eje gastrohipotalámico

Méndez-Sánchez N, Chávez-Tapia NC, Uribe-Esquivel M

Idioma: Español
Referencias bibliográficas: 138
Paginas: 49-58
Archivo PDF: 134.84 Kb.


RESUMEN

La obesidad se considera una de las enfermedades más importantes en la medida que acarrea gran morbilidad y mortalidad. El conocimiento de los mecanismos que intervienen en la saciedad, el peso corporal y el gasto de energía ha permitido el descubrimiento de hormonas relacionadas con el eje gastrohipotalámico, encargado de regular la saciedad y otros procesos que participan en la obesidad. La ghrelina, una hormona de secreción predominantemente gástrica, dio luz para comprender estos mecanismos, pues se trata de una hormona que regula la saciedad y el peso corporal por medio de mecanismos centrales mediados por el neuropéptido Y y la proteína relacionada con el agutí. En este artículo se revisan los aspectos fundamentales de esta hormona y de sus efectos en diversos órganos y sistemas.


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