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ISSN 0185-6014 (Print)
Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2007, Number 3

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Rev Mex Patol Clin Med Lab 2007; 54 (3)

Bucoepithelial cytogenetic alterations in leucoplakia patients

Carnesoltas-Lázaro D, Domínguez-Odio A, Frías-Vázquez AI, Dutok-Sánchez CM, García-Heredia G

Language: Spanish
References: 28
Page: 104-111
PDF size: 123.27 Kb.


ABSTRACT

Leukoplakia is the most common precancerous lesion in oral mucous, but exist many factors that promote their development. The objective of our work was identify and quantify the cytogenetics alterations (micronucleus) and nuclear atypia (binucleation, karyorrhexis, condensed chromatin and karyolysis) in oral cells collected of subjects health and with leukoplakia, and to evaluate their possible relation with exogenous factors (life style). We carry out a case-control study with 43 adults subjects, with a range of 23-75 years old, distributed in two groups, healthy and no healthy subjects. They were asked to determine personal aspects like cigars and alcoholic drink consume and vegetables and fruits consumption. The results suggest that in our study group exist in the subjects with the lesion, a significative increase of nuclear atypia, but low frequency of micronucleus. We determine that sex and age are not important endogen factors in the premalignant process, neither in alterations in frequency of micronucleus and nuclear atypia, but it was different with the tobacco habit and alcoholic drink factors.


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