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Órgano Oficial del Hospital Angeles Health System

2007, Number 3

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Acta Med 2007; 5 (3)

Cancer of the tongue and human papilloma virus (HPV)

Gallegos HJF, Minauro MG, Apresa T, Arias CH, Hernández SM, Flores DR, Reséndiz CJ, Hernández HDM

Language: Spanish
References: 21
Page: 129-133
PDF size: 76.71 Kb.


ABSTRACT

Introduction: Head & Neck squamous cell carcinoma (HNSCC) is the world’s 6th most common cancer. 400,000 HNSCC were diagnosed in 2005 throughout the world, the most frequently affected site is oral cavity. Alcohol-tobacco consumption is the most important risk factor of this neoplasia; nevertheless, since 1983 it was suggested that HPV have a role in HBNSCC mainly in oropharynx (level 1 evidence). Objective: To assess HPV prevalence and types in patients with HNSCC. Material and methods: Presence of HPV was determined by polymerase chain reaction and staged by hybridization in situ. We analyzed stage, tumor site of origin, sex habits, alcohol-tobacco consumption. We performed T test and Fisher’s exact test. We performed a multiple regression analysis for variables’ adjustment. Results: 118 patients; 77 men, 41 women, the most frequent site was oral cavity. Fifty patients (42.3%) were HPV-positive, oropharyngeal and laryngeal cancer patients were the most frequently affected (55% and 50%). HPV-16 was the most frequently isolated (70%). Laryngeal cancer patients suffered the highest ratio of HPV-16 infection (68.7%). Factors associated to HPV (univariate analysis) were: age › 50 years, tobacco-alcohol consumption and male sex, in multivariate analysis none of the variables showed importance (p › 0.5); HPV infection was more frequent in patients with background of alcohol-tobacco (p = 0.6).


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