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Órgano oficial de la Facultad de Odontología, UNAM

2007, Number 4

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Rev Odont Mex 2007; 11 (4)

Participation of interleucine 1β (IL - 1β) in periodontitis

Castrillón RLE, Macín CSA, Palma RA

Language: Spanish
References: 106
Page: 185-200
PDF size: 260.82 Kb.


ABSTRACT

Periodontitis is characterized by a destructive inflammatory process that affects the support tissue of the teeth, the resorption of alveolar bone, the formation of periodontal pockets and eventually the loss of teeth. The proinflammatory cytokines as Interleukin-1 (IL-1), the Tumor necrosis factor alpha (TNFα) and Interferon gamma (IFNγ) are considered the main mediators of chronic inflammation diseases including periodontitis. The high levels of these cytokines in circulation and locally, correlate with the severity of some periodontal diseases suggesting that these molecules participate in host response to develop the progression of this disease. In this review, the characteristics and functions of IL-1 are shown, the main evidences that correlate the induction and progression of periodontal disease with IL-1, the use of this molecule as a prognostic marker and the studies of genetic polymorphism associated with the severity of this disease.


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