Paz-Estrada C, Magendie-Naranjo A, Barzaga-Hernández E

Language: Spanish
References: 29
Page: 136-140
PDF size: 57.83 Kb.

ABSTRACT

Background: Hypertension increases the risk in patients undergoing anesthesia to an unacceptable degree; thus, careful treatment is necessary before surgery to control blood pressure. Objectives: To assess drug-drug interactions occurring with the use of captopril and enalapril during general anesthesia in patients undergoing thyroidectomy. Materials and methods: One hundred and six patients undergoing thyroidectomy were randomized into two groups, each with 53 subjects. Patients in Group I were given captopril 25 mg/kg; patients in Group II were given enalapril 10 mg/kg. Both drugs were given by mouth, two hours before inducing anesthesia. General orotracheal anesthesia was given. Mean blood pressure, heart rate and oxygen saturation were recorded by non-invasive methods at baseline, during induction, throughout surgery and in the postoperative period. Adverse events were also recorded. Results: Mean blood pressure was lower with captopril compared to enalapril throughout the perioperative period (p ‹ 0.05); 39.6% of patients had slight hypotension. Conclusions: Both captopril and enalapril may be used during the perioperative period in patients undergoing thyroidectomy, in spite of the reported side effects.

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