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2007, Number S2

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Arch Cardiol Mex 2007; 77 (S2)

Vasovagal syncope: from genetic to bedside

González-Hermosillo GJA

Language: Spanish
References: 20
Page: 32-36
PDF size: 84.00 Kb.


ABSTRACT

Recent studies suggest vasovagal syncope has a significant heritable component indicating that, at least some forms of vasovagal syncope may have a genetic cause. The β1-adrenergic receptor is a key cell surface signaling protein expressed in the heart and major determinant of cardiac function. The role of genetics in the phenotypic manifestations of vasovagal syncope is unclear. Here, we report the characteristics of several families with several affected members with vasovagal syncope, as well as the results of several genetic studies exploring the prevalence of polymorphisms in the β1 adrenergic receptors which may be associated with vasovagal syncope.


REFERENCES

  1. Newton JL: Prevalence of family history in vasovagal syncope and haemodynamic response to head up tilt in first degree relatives. Preliminary data for the Newcastle cohort. Clin Auton Res 2003; 13: 22-26.

  2. Wieling W, Ganzeboon KS, Philip S: Reflex syncope in children and adolescents. Heart 2004; 90: 1094-1100.

  3. Kochiadakis GE, Papadimitriou EA, Marketou ME, Chrysostomakis SI, Simantirakis EN, vardas PE: Autonomic nervous system changes in vasovagal syncope : Is there any difference between young and older patients? PACE 2004; 27: 1371-1377.

  4. Calkins H, Byrne M, el-Atassi R, Attasi R, Kalbfleisch S, Langberg JJ, Morady F: The economic burden of unrecognized vasodepressor syncope. Am J Med 1993; 95: 473-479.

  5. Camfield PR, Camfiled CS: Syncope in childhood: A case control clinical study of the familial tendency to faint. Can J Neurol Sci 1990; 17: 306-308.

  6. Mathias C, Deguchi K, Bleasdale-Barr K, Smith S: Frequency of family history in vasovagal syncope. Lancet 1998; 352: 33-34.

  7. Newton JL, Kerr S, Pairman J, McLaren A, Norton M, Kenny RA, Morris CM: Familial neurocardiogenic (vasovagal) syncope. Am J of Med Genetics 2005; 133A: 176-179.

  8. Márquez MF, Urias KI, Hermosillo AG, Jardón JL, Iturralde P, Colín L, Nava S, Cárdenas M: Familial vasovagal syncope. Europace 2005;7:472-474

  9. González-Hermosillo A, Márquez MF, Kostine A, Jáuregui-renaud K, Cárdenas M: Vasovagal syncope, orthostatic hypotension and postural orthostatic tachycardia syndrome: Is there a connection? In: Raviele A (Ed). Cardiac Arrhythmias 2003. Milan, Springer, 2004: 615-624.

  10. Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D: Orthostatic intolerance and tachycardia associated with norepinephrine – transporter deficiency. N Engl J Med 2000; 342: 541-549.

  11. Newton JL, Donaldson P, Parry S, Kenny RA, Smith J, Gibson AM, Morris C: Angiotensin converting enzyme insertion/deletion polymorphisms in vasovagal syncope. Europace 2005; 7: 396-399.

  12. Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK: Cloning of the cDNA for the human b1-adrenergic receptor. Proc Natl Acad Sci USA 1987; 84: 7920-7924.

  13. Ranade K, Jorgenson E, Sheu WH, Pei D, Hsiung CH A, Chiang F, Chen YI, Pratt R, Losen RA, Curb D, Cox DR, Bostein D, Rish N: A polymorphism in the b1 adrenergic receptor is associated with resting heart rate. Am J Hum Genet 2002; 70: 935-941.

  14. White HL, Maqbool A, McMahon AD, Yates L, Ball SG, Hall AS, Balmforth AJ: An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals at risk of coronary events. Eur Heart J 2002; 23: 1087-1092.

  15. Mason DA, Moore JD, Green SA, Liggett SB: A gain-of-function polymorphism in a G-protein coupling domain of the human b1-adrenergic receptor. J Biol Chem 1999; 274: 12670-12674.

  16. Sandilands AJ, O’Shaughnessy KM, Brown MJ: Greater inotropic and cyclic AMP responses evoked by noradrenaline through Arg389 beta –adrenoceptors versus Gly389 beta 1-adrenoceptors in isolated human atrial myocardium. Br J Pharmacol 2003; 138: 386-392.

  17. Bruck H, Leinneweber K, Temme T, Weber M, Heush G, Phillipp T, Brodde OE: The Arg389Gly beta 1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. J Am Coll Cardiol 2005; 46: 2111-2115.

  18. Márquez MF, Hérnandez-Pacheco G, Hermosillo AG, Gómez JR, Cárdenas M, Vargas-Alarcón G: Polymorphism of the human b1-adrenergic receptor and susceptibility to faint during head-up tilt test. Heart Rhythm (abstract) 2006; 3: S98.

  19. Fragoso JM, Rodríguez-Pérez JM, Pérez-Vielma N, Martínez-Rodriguez N, Vargas-Alarcón G: Beta 1-adrenergic receptor polymorphisms Arg389Gly and Ser49Gly in the Amerindias and Mestizo populations of Mexico. Human Biology 2005;77:515-520.

  20. Park JL, Sohn DW, Oh BH, Park YB, Choi YS, Kim HS: Genotype of the beta-adrenergic receptor polymorphism was a strong risk factors for neurally mediated syncope. J Am Coll Cardiol 2006; 47: 297A.




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